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PreprintCC BY-NC-NDChemRxiv

Chemical Synthesis of the endogenous metabolite Phosphocitrate and Its Structural Isomer Phosphoisocitrate

  • Petri Turhanen
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Abstract

The first chemical synthesis of phosphoisocitrate [1-(phosphonooxy)propane-1,2,3-tricarboxylic acid, i-PC], a structural isomer of phosphocitrate (PC, natural regulator found in mammalian cells) is reported.Isocitrate is an essential metabolite within the cellular citric acid cycle.Although i-PC may form in vivo via the phosphorylation of isocitrate, it has remained uncharacterized in literature.Phosphocitrate [2-(phosphonooxy)propane-1,2,3-tricarboxylic acid, PC] synthesis was previously reported on a ~200 mg scale.Here an improved synthetic procedure for PC on a multi-gram scale is presented.

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Cite

BibTeXRIS
BibTeX
@misc{turhanen2026chemical,
  title = {{Chemical Synthesis of the endogenous metabolite Phosphocitrate and Its Structural Isomer Phosphoisocitrate}},
  author = {Petri Turhanen},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009122/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009122/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Chemical Synthesis of the endogenous metabolite Phosphocitrate and Its Structural Isomer Phosphoisocitrate
AU  - Petri Turhanen
PY  - 2026
DA  - 2026/09/21
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009122/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009122/v1
AB  - The first chemical synthesis of phosphoisocitrate [1-(phosphonooxy)propane-1,2,3-tricarboxylic acid, i-PC], a structural isomer of phosphocitrate (PC, natural regulator found in mammalian cells) is reported.Isocitrate is an essential metabolite within the cellular citric acid cycle.Although i-PC may form in vivo via the phosphorylation of isocitrate, it has remained uncharacterized in literature.Phosphocitrate [2-(phosphonooxy)propane-1,2,3-tricarboxylic acid, PC] synthesis was previously reported on a ~200 mg scale.Here an improved synthetic procedure for PC on a multi-gram scale is presented.
ER  -