Skip to content
DraconiticResearch
Search Sources API
190,869 studies31 sourcesUpdated 46 min ago
Peer-reviewedCC BY 4.0Frontiers in Endocrinology

Changes in triglyceride-glucose index and progression of coronary artery calcification in asymptomatic adults: a longitudinal cohort study

  • Min Jeong Kim1
  • Yoon Ji Kim1
  • Jae-Heon Kang2,3,4,5
  • Ye Seul Bae1,2
5 affiliations
  1. 1Big Data Research Center, Division of Healthcare Planning, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
  2. 2Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
  3. 3Division of Healthcare Planning, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
  4. 4Institute for Clinical Nutrition, Sungkyunkwan University School of Medicine
  5. 5Institute for Future Healthcare, Sungkyunkwan University School of Medicine
Read full textPDFDOICite

Abstract

Introduction: The triglyceride-glucose (TyG) index is a readily available surrogate marker of insulin resistance; however, the association between changes in TyG index and coronary artery calcification (CAC) progression remains unclear.

Methods: This retrospective cohort study included 14,407 Korean adults without cardiovascular disease who underwent two baseline examinations during 2012–2018 and at least three examinations overall. At each baseline examination, TyG index status was classified as low or high using a predefined cutoff, yielding low-to-low (L-L), low-to-high (L-H), high-to-low (H-L), and high-to-high (H-H) groups. CAC progression was defined as a difference of ≥2.5 between the square root-transformed coronary artery calcium score (CACS) of the follow-up and index examination. Cox proportional hazards and linear mixed-effects models were used to estimate hazard ratios (HRs) and 5-year fold changes, respectively.

Results: During a median follow-up of 5.34 years, 4,139 participants experienced CAC progression. Compared with the L-L group, the risk of CAC progression increased across the L-H, H-L, and H-H groups, with adjusted HRs (95% confidence intervals) of 1.07 (0.96–1.19), 1.14 (1.02–1.27), and 1.30 (1.20–1.41), respectively. Associations differed between CAC subgroups ( p for interaction <0.001), with more pronounced associations observed among participants with CACS of zero at both the first and index examinations. The 5-year fold change was 11% higher in the L-H group than in the L-L group and 9% lower in the H-L group than in the H-H group.

Conclusion: Changes in TyG index status were associated with CAC progression, particularly among individuals without detectable CAC. Serial TyG index assessment may aid in cardiovascular risk stratification.

Related

  1. Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression
    Shaun Khanna, G. V. Mann, Sohaib A. Virk +9
    JACC AdvancesPeer-reviewedCC BY-NC-ND10 citedMedical imaging & radiologyOpenAlex
  2. Visit-to-visit variability and longitudinal change of the triglyceride-glucose index are associated with early carotid plaque progression.
    Pan Tang, Min Cui, Ru Li +2
    BMC cardiovascular disordersPeer-reviewedCC BY-NC-NDFull textEndocrinology & metabolismEurope PMCDOAJ
  3. A Case of Asymptomatic Carotid Artery Stenosis With Thumb‐Sized Calcification Detected on Panoramic Radiograph
    Kosei Shibata, Keiko Kaneko, Tatsuo Takaya +13
    Clinical case reportsPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMCEurope PMC
  4. Serum T50 is not independently associated with coronary artery calcification in early chronic kidney disease
    Clinical kidney journalPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  5. Segment-Level Evaluability of Dedicated Non-ECG-Gated Coronary CT Angiography: Associations with Calcification, Heart Rate, Vessel Territory, and Caliber
    Kun Wang, Aiyun Sun, Xia Qiu +3
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{kim2026changes,
  title = {{Changes in triglyceride-glucose index and progression of coronary artery calcification in asymptomatic adults: a longitudinal cohort study}},
  author = {Min Jeong Kim and Yoon Ji Kim and Jae-Heon Kang and Ye Seul Bae},
  journal = {Frontiers in Endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1976562},
  url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1976562/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Changes in triglyceride-glucose index and progression of coronary artery calcification in asymptomatic adults: a longitudinal cohort study
AU  - Min Jeong Kim
AU  - Yoon Ji Kim
AU  - Jae-Heon Kang
AU  - Ye Seul Bae
PY  - 2026
DA  - 2026/10/08
JO  - Frontiers in Endocrinology
DO  - 10.3389/fendo.2026.1976562
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2026.1976562/full
AB  - Introduction: The triglyceride-glucose (TyG) index is a readily available surrogate marker of insulin resistance; however, the association between changes in TyG index and coronary artery calcification (CAC) progression remains unclear.  Methods: This retrospective cohort study included 14,407 Korean adults without cardiovascular disease who underwent two baseline examinations during 2012–2018 and at least three examinations overall. At each baseline examination, TyG index status was classified as low or high using a predefined cutoff, yielding low-to-low (L-L), low-to-high (L-H), high-to-low (H-L), and high-to-high (H-H) groups. CAC progression was defined as a difference of ≥2.5 between the square root-transformed coronary artery calcium score (CACS) of the follow-up and index examination. Cox proportional hazards and linear mixed-effects models were used to estimate hazard ratios (HRs) and 5-year fold changes, respectively.  Results: During a median follow-up of 5.34 years, 4,139 participants experienced CAC progression. Compared with the L-L group, the risk of CAC progression increased across the L-H, H-L, and H-H groups, with adjusted HRs (95% confidence intervals) of 1.07 (0.96–1.19), 1.14 (1.02–1.27), and 1.30 (1.20–1.41), respectively. Associations differed between CAC subgroups ( p for interaction <0.001), with more pronounced associations observed among participants with CACS of zero at both the first and index examinations. The 5-year fold change was 11% higher in the L-H group than in the L-L group and 9% lower in the H-L group than in the H-H group.  Conclusion: Changes in TyG index status were associated with CAC progression, particularly among individuals without detectable CAC. Serial TyG index assessment may aid in cardiovascular risk stratification.
SN  - 1664-2392
ER  -