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Peer-reviewedCC BY 4.0Polymers

Polymer-Based Additive Manufacturing in Cervical Cancer Management: A Review

  • Xiaolong Wang1,2
  • Nanshan Lin1
  • Yiqiong Cao1
  • Jaydeep Vishwakarma2
  • Xianhu Liu3
  • Chenchen Ren1,4,5
5 affiliations
  1. 1Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou 450002, China
  2. 2Équipe de Recherche sur les Processus Innovatifs (ERPI), Université de Lorraine, F-54000 Nancy, France
  3. 3National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, China
  4. 4Zhengzhou Key Laboratory of Cervical Diseases, Zhengzhou 450052, China
  5. 5National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, Zhengzhou 450052, China
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Abstract

Cervical cancer management increasingly requires patient-specific and locally adaptable technologies to address complex pelvic anatomy, heterogeneous tumor geometry, limited local drug retention, and the need for improved planning and education. Polymer-based additive manufacturing offers a promising strategy by integrating digital design, customizable three-dimensional geometry, and tunable material properties. This review summarizes recent progress in polymer-based additive manufacturing for cervical-cancer-related applications from a material–process–structure–function perspective. Four application domains are discussed: 3D-printed polymeric devices for brachytherapy assistance, therapeutic scaffolds and local delivery systems, bioprinted research platforms, and patient-specific anatomical models for education, planning, and communication. In brachytherapy, printable templates and applicator accessories can improve anatomical adaptation, needle guidance, and procedural reproducibility. In therapeutic scaffolds, polymers enable local retention, controlled release, mechanical support, mucoadhesion, and mucosal interface regulation. In bioprinted tumor models, hydrogel bioinks provide controllable three-dimensional microenvironments for studying spheroid formation, epithelial–mesenchymal transition, drug response, oxygen gradients, and molecular diffusion. Patient-specific anatomical models further support spatial understanding, procedural training, multidisciplinary communication, and patient-centered decision-making. Future progress will depend on standardized workflows, clinically relevant validation, material safety evaluation, and integration with personalized oncology.

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Cite

BibTeXRIS
BibTeX
@article{wang2026polymerbased,
  title = {{Polymer-Based Additive Manufacturing in Cervical Cancer Management: A Review}},
  author = {Xiaolong Wang and Nanshan Lin and Yiqiong Cao and Jaydeep Vishwakarma and Xianhu Liu and Chenchen Ren},
  journal = {Polymers},
  year = {2026},
  month = oct,
  doi = {10.3390/polym18202455},
  url = {https://www.mdpi.com/2073-4360/18/20/2455},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Polymer-Based Additive Manufacturing in Cervical Cancer Management: A Review
AU  - Xiaolong Wang
AU  - Nanshan Lin
AU  - Yiqiong Cao
AU  - Jaydeep Vishwakarma
AU  - Xianhu Liu
AU  - Chenchen Ren
PY  - 2026
DA  - 2026/10/01
JO  - Polymers
DO  - 10.3390/polym18202455
UR  - https://www.mdpi.com/2073-4360/18/20/2455
AB  - Cervical cancer management increasingly requires patient-specific and locally adaptable technologies to address complex pelvic anatomy, heterogeneous tumor geometry, limited local drug retention, and the need for improved planning and education. Polymer-based additive manufacturing offers a promising strategy by integrating digital design, customizable three-dimensional geometry, and tunable material properties. This review summarizes recent progress in polymer-based additive manufacturing for cervical-cancer-related applications from a material–process–structure–function perspective. Four application domains are discussed: 3D-printed polymeric devices for brachytherapy assistance, therapeutic scaffolds and local delivery systems, bioprinted research platforms, and patient-specific anatomical models for education, planning, and communication. In brachytherapy, printable templates and applicator accessories can improve anatomical adaptation, needle guidance, and procedural reproducibility. In therapeutic scaffolds, polymers enable local retention, controlled release, mechanical support, mucoadhesion, and mucosal interface regulation. In bioprinted tumor models, hydrogel bioinks provide controllable three-dimensional microenvironments for studying spheroid formation, epithelial–mesenchymal transition, drug response, oxygen gradients, and molecular diffusion. Patient-specific anatomical models further support spatial understanding, procedural training, multidisciplinary communication, and patient-centered decision-making. Future progress will depend on standardized workflows, clinically relevant validation, material safety evaluation, and integration with personalized oncology.
SN  - 2073-4360
ER  -