Molecular profile of micronutrient-producing microorganisms following Martian mission-relevant ionizing radiation dose rate exposure
Abstract
This study evaluated the radiation tolerance, biomass production, vitamin biosynthesis, and whole-proteome response of three edible extremotolerant microorganisms, i.e., Debaryomyces hansenii DSM 3428, Bacillus subtilis DSM 10, and Limosilactobacillus reuteri DSM 20016, under a Martian mission-relevant ionizing radiation dose rate. Cultures were exposed to Martian cruise and Martian surface dose rates of gamma ionizing radiation, using γ-rays of a 60Co source. Biomass yield and riboflavin content of irradiated cultures were analyzed. Proteomic analyses were conducted for the bacteria B. subtilis and L. reuteri, for which well-annotated reference genomes and proteomes were available. Also, post-irradiation regrowth characteristics were tested. D. hansenii and B. subtilis showed no significant impairment in growth rate post-irradiation, biomass production, or riboflavin synthesis during chronic exposure, and normal post-irradiation regrowth, similar to non-exposed cultures. In contrast, L. reuteri exhibited a higher radiation sensitivity, with a reduced biomass yield in the irradiated cultures, and an altered post-irradiation growth profile.
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BibTeX
@article{ellena2026molecular,
title = {{Molecular profile of micronutrient-producing microorganisms following Martian mission-relevant ionizing radiation dose rate exposure}},
author = {Gabriele Ellena and Arianna Mazzoli and Surya Gupta and Irina Spacova and Natalie Leys and Sarah Lebeer and Felice Mastroleo},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.117979},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03362-6},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Molecular profile of micronutrient-producing microorganisms following Martian mission-relevant ionizing radiation dose rate exposure
AU - Gabriele Ellena
AU - Arianna Mazzoli
AU - Surya Gupta
AU - Irina Spacova
AU - Natalie Leys
AU - Sarah Lebeer
AU - Felice Mastroleo
PY - 2026
DA - 2026/10/23
JO - iScience
DO - 10.1016/j.isci.2026.117979
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03362-6
AB - This study evaluated the radiation tolerance, biomass production, vitamin biosynthesis, and whole-proteome response of three edible extremotolerant microorganisms, i.e., Debaryomyces hansenii DSM 3428, Bacillus subtilis DSM 10, and Limosilactobacillus reuteri DSM 20016, under a Martian mission-relevant ionizing radiation dose rate. Cultures were exposed to Martian cruise and Martian surface dose rates of gamma ionizing radiation, using γ-rays of a 60Co source. Biomass yield and riboflavin content of irradiated cultures were analyzed. Proteomic analyses were conducted for the bacteria B. subtilis and L. reuteri, for which well-annotated reference genomes and proteomes were available. Also, post-irradiation regrowth characteristics were tested. D. hansenii and B. subtilis showed no significant impairment in growth rate post-irradiation, biomass production, or riboflavin synthesis during chronic exposure, and normal post-irradiation regrowth, similar to non-exposed cultures. In contrast, L. reuteri exhibited a higher radiation sensitivity, with a reduced biomass yield in the irradiated cultures, and an altered post-irradiation growth profile.
SN - 2589-0042
ER -