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Peer-reviewedCC BY-NC-NDJournal of the American Heart Association

Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife

  • Sebastian Herlitz1,2
  • Agnes Wahrenberg1,2
  • Henrike Häbel3
  • Göran Bergström4
  • Gunnar Engström5
  • Emil Hagström6
  • Tomas Jernberg7
  • Lars Lind6
  • Stefan Söderberg8
  • Carl Johan Östgren9
  • Joel Ohm3,10
  • Per Svensson1,2
10 affiliations
  1. 1Södersjukhuset, Karolinska Institutet
  2. 2Södersjukhuset
  3. 3Karolinska Institutet
  4. 4University of Gothenburg
  5. 5Lund University
  6. 6Uppsala University
  7. 7Danderyd University Hospital, Karolinska Institutet
  8. 8Umeå University
  9. 9Linköping University
  10. 10Karolinska University Hospital
Open at sourceDOICite

Abstract

BACKGROUND: Socioeconomic status (SES) is a major risk factor for coronary heart disease, but the life-course mechanisms and causal pathways remain poorly understood. Therefore, we investigated whether low childhood SES was associated with midlife coronary atherosclerosis and if any association could be explained by established risk factors in adulthood. METHODS: This observational cohort study included 15 640 participants, aged 50 to 64 years, from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) who underwent coronary computed tomography angiography. Coronary atherosclerosis was assessed by segment involvement score and coronary artery calcification score. Childhood SES was defined by parental disposable income at participant age 10 to 12 years retrieved from national registers. Associations between moderate-severe coronary atherosclerosis (segment involvement score ≥4 or coronary artery calcification >100) and childhood SES were estimated using multivariable logistic regression adjusting for adult lifestyle habits, adult SES, and traditional cardiovascular risk factors. RESULTS: =0.010). Similar associations were observed for coronary artery calcification >100. CONCLUSIONS: Low childhood SES was associated with moderate-severe coronary atherosclerosis in midlife only partially explained by established risk factors in adulthood. Our findings suggest that childhood SES is a social determinant of long-term cardiovascular health that cannot be fully explained by established adult risk factors.

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Cite

BibTeXRIS
BibTeX
@article{herlitz2026parental,
  title = {{Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife}},
  author = {Sebastian Herlitz and Agnes Wahrenberg and Henrike Häbel and Göran Bergström and Gunnar Engström and Emil Hagström and Tomas Jernberg and Lars Lind and Stefan Söderberg and Carl Johan Östgren and Joel Ohm and Per Svensson},
  journal = {Journal of the American Heart Association},
  year = {2026},
  month = oct,
  doi = {10.1161/jaha.126.050332},
  url = {https://www.ahajournals.org/doi/10.1161/JAHA.126.050332},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife
AU  - Sebastian Herlitz
AU  - Agnes Wahrenberg
AU  - Henrike Häbel
AU  - Göran Bergström
AU  - Gunnar Engström
AU  - Emil Hagström
AU  - Tomas Jernberg
AU  - Lars Lind
AU  - Stefan Söderberg
AU  - Carl Johan Östgren
AU  - Joel Ohm
AU  - Per Svensson
PY  - 2026
DA  - 2026/10/20
JO  - Journal of the American Heart Association
DO  - 10.1161/jaha.126.050332
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.126.050332
AB  - BACKGROUND: Socioeconomic status (SES) is a major risk factor for coronary heart disease, but the life-course mechanisms and causal pathways remain poorly understood. Therefore, we investigated whether low childhood SES was associated with midlife coronary atherosclerosis and if any association could be explained by established risk factors in adulthood. METHODS: This observational cohort study included 15 640 participants, aged 50 to 64 years, from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) who underwent coronary computed tomography angiography. Coronary atherosclerosis was assessed by segment involvement score and coronary artery calcification score. Childhood SES was defined by parental disposable income at participant age 10 to 12 years retrieved from national registers. Associations between moderate-severe coronary atherosclerosis (segment involvement score ≥4 or coronary artery calcification >100) and childhood SES were estimated using multivariable logistic regression adjusting for adult lifestyle habits, adult SES, and traditional cardiovascular risk factors. RESULTS: =0.010). Similar associations were observed for coronary artery calcification >100. CONCLUSIONS: Low childhood SES was associated with moderate-severe coronary atherosclerosis in midlife only partially explained by established risk factors in adulthood. Our findings suggest that childhood SES is a social determinant of long-term cardiovascular health that cannot be fully explained by established adult risk factors.
SN  - 2047-9980
ER  -