Sedentary Behavior, Physical Activity, and Sleep During Pregnancy and Offspring Health: Protocol for the Pregnancy 24/7 Offspring Multi‐Site Cohort Study
4 affiliations
- 1University of Iowa
- 2Oakland University
- 3University of Pittsburgh
- 4West Virginia University
Abstract
BACKGROUND: Childhood obesity is a major public health concern that increases cardiovascular disease (CVD) risk. The Developmental Origins of Health and Disease theory posits that obesity and CVD risk is, in part, programmed in utero. A greater understanding of modifiable maternal factors that associate with offspring obesity and CVD risk in childhood could inform primordial prevention interventions during pregnancy. Maternal sedentary behavior, physical activity, and sleep during pregnancy are modifiable and plausible determinants of offspring obesity and CVD risk yet remain insufficiently studied. This protocol describes the design of the Pregnancy 24/7 Offspring Study (NCT07172880), developed to address this gap in knowledge. METHODS: This study examines associations between device-based maternal 24-hour movement behavior (sedentary behavior, physical activity, and sleep) measured in each pregnancy trimester and analyzed via trajectories and as compositions with offspring obesity and CVD risk through 24 months of age. Maternal 24-hour movement behavior data and birth outcomes were previously collected in the Pregnancy 24/7 Cohort Study (N=500, Iowa, Pennsylvania, and West Virginia). The Offspring study extends this cohort by enrolling up to 450 maternal-offspring dyads and collecting new measures in the offspring, including body mass index z-score from birth through 24 months obtained via medical record abstraction, anthropometry, indicators of CVD risk, and maternal questionnaires. The primary outcome is body mass index z-score trajectory; secondary outcomes include adiposity, blood pressure, and brachial-femoral pulse wave velocity. CONCLUSIONS: Findings from this study will advance understanding of how maternal 24-hour activity associates with early-life obesity and CVD risk, informing primordial prevention strategies during pregnancy.
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BibTeX
@article{whitaker2026sedentary,
title = {{Sedentary Behavior, Physical Activity, and Sleep During Pregnancy and Offspring Health: Protocol for the Pregnancy 24/7 Offspring Multi‐Site Cohort Study}},
author = {Kara M. Whitaker and Melissa A. Jones and Alex H. Crisp and Jaemyung Kim and Sharon E. Taverno Ross and Brooke N. Anthos and Taylor Marske and Sabera Rahman and J. P. Marrero‐Rivera and Alexis Thrower and Maisa Feghali and Treah Haggerty and Emily Mozena and Robert Roghair and Bridget Zimmerman and Bethany Barone Gibbs},
journal = {Journal of the American Heart Association},
year = {2026},
month = oct,
doi = {10.1161/jaha.126.050797},
url = {https://www.ahajournals.org/doi/10.1161/JAHA.126.050797},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Sedentary Behavior, Physical Activity, and Sleep During Pregnancy and Offspring Health: Protocol for the Pregnancy 24/7 Offspring Multi‐Site Cohort Study
AU - Kara M. Whitaker
AU - Melissa A. Jones
AU - Alex H. Crisp
AU - Jaemyung Kim
AU - Sharon E. Taverno Ross
AU - Brooke N. Anthos
AU - Taylor Marske
AU - Sabera Rahman
AU - J. P. Marrero‐Rivera
AU - Alexis Thrower
AU - Maisa Feghali
AU - Treah Haggerty
AU - Emily Mozena
AU - Robert Roghair
AU - Bridget Zimmerman
AU - Bethany Barone Gibbs
PY - 2026
DA - 2026/10/20
JO - Journal of the American Heart Association
DO - 10.1161/jaha.126.050797
UR - https://www.ahajournals.org/doi/10.1161/JAHA.126.050797
AB - BACKGROUND: Childhood obesity is a major public health concern that increases cardiovascular disease (CVD) risk. The Developmental Origins of Health and Disease theory posits that obesity and CVD risk is, in part, programmed in utero. A greater understanding of modifiable maternal factors that associate with offspring obesity and CVD risk in childhood could inform primordial prevention interventions during pregnancy. Maternal sedentary behavior, physical activity, and sleep during pregnancy are modifiable and plausible determinants of offspring obesity and CVD risk yet remain insufficiently studied. This protocol describes the design of the Pregnancy 24/7 Offspring Study (NCT07172880), developed to address this gap in knowledge. METHODS: This study examines associations between device-based maternal 24-hour movement behavior (sedentary behavior, physical activity, and sleep) measured in each pregnancy trimester and analyzed via trajectories and as compositions with offspring obesity and CVD risk through 24 months of age. Maternal 24-hour movement behavior data and birth outcomes were previously collected in the Pregnancy 24/7 Cohort Study (N=500, Iowa, Pennsylvania, and West Virginia). The Offspring study extends this cohort by enrolling up to 450 maternal-offspring dyads and collecting new measures in the offspring, including body mass index z-score from birth through 24 months obtained via medical record abstraction, anthropometry, indicators of CVD risk, and maternal questionnaires. The primary outcome is body mass index z-score trajectory; secondary outcomes include adiposity, blood pressure, and brachial-femoral pulse wave velocity. CONCLUSIONS: Findings from this study will advance understanding of how maternal 24-hour activity associates with early-life obesity and CVD risk, informing primordial prevention strategies during pregnancy.
SN - 2047-9980
ER -