Smart Thermosensitive Mesoporous Silica Composites for Precisely Triggered Linalool Release

Abstract

To overcome the application limitations of linalool, including its high volatility and poor stability, mesoporous silica MCM-41 was used as the carrier, and N-isopropylacrylamide (NIPAM) was employed as the thermosensitive monomer in this study. Acrylamide (AM) was introduced to modulate the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM), while N,N′-methylenebis(acrylamide) (BIS), used as a cross-linking agent, was added to enhance structural stability, thus constructing the MCM-41-PNIPAM thermosensitive composite sustained-release system. Characterization results confirmed the successful synthesis of the target material, whose LCST increased to 82–85 °C with the increasing AM doping ratio. Sustained-release experiments indicated that the release rate of linalool significantly increased when the environmental temperature exceeded the LCST. Antibacterial tests revealed that the composite exhibited a remarkable inhibitory effect on Bacillus subtilis, Staphylococcus aureus, and Escherichia coli following the temperature-triggered release of linalool. Moreover, the antibacterial effect could be precisely controlled by regulating the ambient temperature, thereby modulating the release. This study presents a new strategy for the stabilized application of linalool, achieves an intelligent response effect of “temperature-triggered and on-demand release,” and offered a universal method for constructing intelligent preservation systems.

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Cite

BibTeX RIS

BibTeX

@article{gao2026smart,
  title = {{Smart Thermosensitive Mesoporous Silica Composites for Precisely Triggered Linalool Release}},
  author = {Zhenhui Gao and Yanhua Lu and Fengfeng Zhang and Wenlong Bao and Xinhua Song and Fanyu Kong and Rongning Liang and Dean Song},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c04870},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c04870/5459658/Smart-Thermosensitive-Mesoporous-Silica-Composites},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Smart Thermosensitive Mesoporous Silica Composites for Precisely Triggered Linalool Release
AU  - Zhenhui Gao
AU  - Yanhua Lu
AU  - Fengfeng Zhang
AU  - Wenlong Bao
AU  - Xinhua Song
AU  - Fanyu Kong
AU  - Rongning Liang
AU  - Dean Song
PY  - 2026
DA  - 2026/10/28
JO  - ACS Omega
DO  - 10.1021/acsomega.6c04870
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c04870/5459658/Smart-Thermosensitive-Mesoporous-Silica-Composites
AB  - To overcome the application limitations of linalool, including its high volatility and poor stability, mesoporous silica MCM-41 was used as the carrier, and N-isopropylacrylamide (NIPAM) was employed as the thermosensitive monomer in this study. Acrylamide (AM) was introduced to modulate the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM), while N,N′-methylenebis(acrylamide) (BIS), used as a cross-linking agent, was added to enhance structural stability, thus constructing the MCM-41-PNIPAM thermosensitive composite sustained-release system. Characterization results confirmed the successful synthesis of the target material, whose LCST increased to 82–85 °C with the increasing AM doping ratio. Sustained-release experiments indicated that the release rate of linalool significantly increased when the environmental temperature exceeded the LCST. Antibacterial tests revealed that the composite exhibited a remarkable inhibitory effect on Bacillus subtilis, Staphylococcus aureus, and Escherichia coli following the temperature-triggered release of linalool. Moreover, the antibacterial effect could be precisely controlled by regulating the ambient temperature, thereby modulating the release. This study presents a new strategy for the stabilized application of linalool, achieves an intelligent response effect of “temperature-triggered and on-demand release,” and offered a universal method for constructing intelligent preservation systems.
SN  - 2470-1343
ER  -

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