Prevalence and prognostic significance of obstructive sleep apnea in patients with idiopathic pulmonary fibrosis: A prospective cohort study.
- 1Department of Chest Diseases, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul, Türkiye.
- 2Department of Chest Diseases, Sleep Laboratory, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul, Türkiye.
Abstract
Background
Obstructive sleep apnea (OSA) is a recognized comorbidity in idiopathic pulmonary fibrosis (IPF); however, its true prevalence remains uncertain, and its prognostic implications have not been fully elucidated. This study aimed to determine the prevalence of and risk factors for OSA in patients with IPF and to evaluate its impact on disease progression.Methods
This prospective study enrolled 50 patients with IPF followed at a tertiary care center. All patients underwent polysomnography (PSG), and OSA was classified as mild, moderate, or severe. The Berlin Questionnaire and the Epworth Sleepiness Scale were administered prior to PSG. Forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (DLCO) were measured at baseline and at 1 year. Disease progression was defined as a ≥10% decline in FVC and/or a ≥15% decline in DLCO.Results
The mean age was 67.8 ± 6.7 years, and 80% were male. OSA prevalence was 90.0% (95% confidence interval: 78.2-96.7), with mild, moderate, and severe disease each present in 30% of patients. Moderate-to-severe OSA was associated with significantly greater pulmonary function decline (P = 0.030). Hypertension and high-risk status on the Berlin Questionnaire were significantly associated with the presence of OSA.Conclusions
OSA prevalence in IPF is remarkably high, with the majority having moderate-to-severe disease. The Berlin Questionnaire may serve as a reliable screening tool for PSG candidacy in this population. These findings suggest that OSA may contribute to functional disease progression in patients with IPF.
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BibTeX
@article{erten2026prevalence,
title = {{Prevalence and prognostic significance of obstructive sleep apnea in patients with idiopathic pulmonary fibrosis: A prospective cohort study.}},
author = {Hasibe Çigdem Erten and Sevda Sener Cömert and Gülten Aktin Güngör and Elif Yilmaz and Ayse Havan and Nesrin Kiral},
journal = {Annals of thoracic medicine},
year = {2026},
month = sep,
doi = {10.4103/atm.atm_84_26},
url = {https://europepmc.org/article/MED/42936363},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Prevalence and prognostic significance of obstructive sleep apnea in patients with idiopathic pulmonary fibrosis: A prospective cohort study.
AU - Hasibe Çigdem Erten
AU - Sevda Sener Cömert
AU - Gülten Aktin Güngör
AU - Elif Yilmaz
AU - Ayse Havan
AU - Nesrin Kiral
PY - 2026
DA - 2026/09/03
JO - Annals of thoracic medicine
DO - 10.4103/atm.atm_84_26
UR - https://europepmc.org/article/MED/42936363
AB - Background Obstructive sleep apnea (OSA) is a recognized comorbidity in idiopathic pulmonary fibrosis (IPF); however, its true prevalence remains uncertain, and its prognostic implications have not been fully elucidated. This study aimed to determine the prevalence of and risk factors for OSA in patients with IPF and to evaluate its impact on disease progression.Methods This prospective study enrolled 50 patients with IPF followed at a tertiary care center. All patients underwent polysomnography (PSG), and OSA was classified as mild, moderate, or severe. The Berlin Questionnaire and the Epworth Sleepiness Scale were administered prior to PSG. Forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (DLCO) were measured at baseline and at 1 year. Disease progression was defined as a ≥10% decline in FVC and/or a ≥15% decline in DLCO.Results The mean age was 67.8 ± 6.7 years, and 80% were male. OSA prevalence was 90.0% (95% confidence interval: 78.2-96.7), with mild, moderate, and severe disease each present in 30% of patients. Moderate-to-severe OSA was associated with significantly greater pulmonary function decline (P = 0.030). Hypertension and high-risk status on the Berlin Questionnaire were significantly associated with the presence of OSA.Conclusions OSA prevalence in IPF is remarkably high, with the majority having moderate-to-severe disease. The Berlin Questionnaire may serve as a reliable screening tool for PSG candidacy in this population. These findings suggest that OSA may contribute to functional disease progression in patients with IPF.
SN - 1817-1737
SN - 1998-3557
ER -