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Peer-reviewedCC BY-NC-NDAlzheimer's & dementia : the journal of the Alzheimer's Association

MRI-derived glymphatic-related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults.

  • Zhan Wang1
  • Guojun Lin2
  • Fang Fang3,4
  • Jing Yu1
4 affiliations
  1. 1Faculty of Psychology, Southwest University, Chongqing, China.
  2. 2State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
  3. 3Department of Neurology, University-Town Hospital of Chongqing Medical University, Chongqing, China.
  4. 4Chongqing Medical University, Chongqing, China.
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Abstract

Introduction

We evaluated a multimodal magnetic resonance imaging (MRI)-derived glymphatic-related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults.Methods

Ninety-two participants were included in the baseline analyses and 68 in the 6-month reassessment analyses. Cardiovascular risk was estimated using the Prediction for ASCVD Risk in China 10-year atherosclerotic cardiovascular disease score. The glymphatic-related composite integrated six MRI-derived measures: choroid plexus volume, choroid plexus free-water fraction, diffusion tensor image analysis along the perivascular space index, blood oxygen level-dependent signal-cerebrospinal fluid coupling, basal ganglia perivascular spaces, and deep white matter perivascular spaces. Outcomes included cortical thickness in Alzheimer's disease (AD)-vulnerable regions, peak width of skeletonized mean diffusivity, and cognitive performance.Results

Higher cardiovascular risk was associated with lower glymphatic-related composite scores and lower cortical thickness in AD-vulnerable regions at baseline and the 6-month reassessment. Higher cardiovascular risk was also indirectly associated with poorer flanker task performance through the glymphatic-related composite at both assessments.Discussion

The MRI-derived glymphatic-related composite showed consistent associations with cardiovascular risk and cognitive vulnerability across repeated assessments and may serve as a summary measure of glymphatic-related MRI features in older adults.

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Cite

BibTeXRIS
BibTeX
@article{wang2026mriderived,
  title = {{MRI-derived glymphatic-related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults.}},
  author = {Zhan Wang and Guojun Lin and Fang Fang and Jing Yu},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year = {2026},
  month = oct,
  doi = {10.1002/alz.71961},
  url = {https://europepmc.org/article/MED/42967579},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - MRI-derived glymphatic-related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults.
AU  - Zhan Wang
AU  - Guojun Lin
AU  - Fang Fang
AU  - Jing Yu
PY  - 2026
DA  - 2026/10/01
JO  - Alzheimer's & dementia : the journal of the Alzheimer's Association
DO  - 10.1002/alz.71961
UR  - https://europepmc.org/article/MED/42967579
AB  - Introduction  We evaluated a multimodal magnetic resonance imaging (MRI)-derived glymphatic-related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults.Methods  Ninety-two participants were included in the baseline analyses and 68 in the 6-month reassessment analyses. Cardiovascular risk was estimated using the Prediction for ASCVD Risk in China 10-year atherosclerotic cardiovascular disease score. The glymphatic-related composite integrated six MRI-derived measures: choroid plexus volume, choroid plexus free-water fraction, diffusion tensor image analysis along the perivascular space index, blood oxygen level-dependent signal-cerebrospinal fluid coupling, basal ganglia perivascular spaces, and deep white matter perivascular spaces. Outcomes included cortical thickness in Alzheimer's disease (AD)-vulnerable regions, peak width of skeletonized mean diffusivity, and cognitive performance.Results  Higher cardiovascular risk was associated with lower glymphatic-related composite scores and lower cortical thickness in AD-vulnerable regions at baseline and the 6-month reassessment. Higher cardiovascular risk was also indirectly associated with poorer flanker task performance through the glymphatic-related composite at both assessments.Discussion  The MRI-derived glymphatic-related composite showed consistent associations with cardiovascular risk and cognitive vulnerability across repeated assessments and may serve as a summary measure of glymphatic-related MRI features in older adults.
SN  - 1552-5260
SN  - 1552-5279
ER  -