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Peer-reviewedCC BY 4.0Molecules

Identification of an Inhibitory Fraction from Cinnamomum cassia Against Digestive Lipases

  • Sihem Snini1,2
  • Jannet Kamoun2
  • Peter Balogun1
  • Michele Fiore1
  • Sébastien Violot3
  • Mohamed Sellami2
  • Sophie Ayciriex1,4
  • Alexandre Noiriel1
  • Ahmed Aloulou2
  • Abdelkarim Abousalham1
4 affiliations
  1. 1Université Lyon 1, CNRS, ICBMS, UMR 5246, Villeurbanne, France
  2. 2Laboratory of Biochemistry and Enzymatic Engineering of Lipases, National Engineering School of Sfax, University of Sfax, Sfax 3038, Tunisia
  3. 3Molecular Microbiology and Structural Biochemistry (MMSB), UMR 5086, CNRS, Université Lyon 1, 7 Passage du Vercors, Cedex 07, F-69367 Lyon, France
  4. 4The Lyon Hepatology Institute, IHU EVEREST, F-69424 Lyon, France
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Abstract

Natural inhibitors of digestive lipases offer promising alternatives to conventional obesity medications. This study screened nine medicinal plant extracts, identifying the ethanolic bark extract of Cinnamomum cassia as the most potent inhibitor for gastric and pancreatic lipases. Using an integrated approach combining bioactivity-guided fractionation and mass spectrometry, we isolated the highly active fraction, F3-1-1, which exhibited dose- and time-dependent inhibitory effects against human and porcine pancreatic lipases, as well as dog gastric lipase (DGL). Further mass spectrometry and peptide mass fingerprint analysis putatively annotated cinncassiol A-19 glucoside as a bioactive constituent. Notably, this compound was likely bound covalently to the catalytic peptide containing the Ser153 residue in DGL, characterized by a mass shift of +553.10 Da. Molecular docking simulations supported these suggestions, demonstrating stable interactions within the catalytic pocket of DGL through hydrogen and hydrophobic bond interactions. These findings highlight C. cassia as a promising source of natural anti-obesity agents.

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Cite

BibTeXRIS
BibTeX
@article{snini2026identification,
  title = {{Identification of an Inhibitory Fraction from Cinnamomum cassia Against Digestive Lipases}},
  author = {Sihem Snini and Jannet Kamoun and Peter Balogun and Michele Fiore and Sébastien Violot and Mohamed Sellami and Sophie Ayciriex and Alexandre Noiriel and Ahmed Aloulou and Abdelkarim Abousalham},
  journal = {Molecules},
  year = {2026},
  month = oct,
  doi = {10.3390/molecules31203737},
  url = {https://www.mdpi.com/1420-3049/31/20/3737},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Identification of an Inhibitory Fraction from Cinnamomum cassia Against Digestive Lipases
AU  - Sihem Snini
AU  - Jannet Kamoun
AU  - Peter Balogun
AU  - Michele Fiore
AU  - Sébastien Violot
AU  - Mohamed Sellami
AU  - Sophie Ayciriex
AU  - Alexandre Noiriel
AU  - Ahmed Aloulou
AU  - Abdelkarim Abousalham
PY  - 2026
DA  - 2026/10/01
JO  - Molecules
DO  - 10.3390/molecules31203737
UR  - https://www.mdpi.com/1420-3049/31/20/3737
AB  - Natural inhibitors of digestive lipases offer promising alternatives to conventional obesity medications. This study screened nine medicinal plant extracts, identifying the ethanolic bark extract of Cinnamomum cassia as the most potent inhibitor for gastric and pancreatic lipases. Using an integrated approach combining bioactivity-guided fractionation and mass spectrometry, we isolated the highly active fraction, F3-1-1, which exhibited dose- and time-dependent inhibitory effects against human and porcine pancreatic lipases, as well as dog gastric lipase (DGL). Further mass spectrometry and peptide mass fingerprint analysis putatively annotated cinncassiol A-19 glucoside as a bioactive constituent. Notably, this compound was likely bound covalently to the catalytic peptide containing the Ser153 residue in DGL, characterized by a mass shift of +553.10 Da. Molecular docking simulations supported these suggestions, demonstrating stable interactions within the catalytic pocket of DGL through hydrogen and hydrophobic bond interactions. These findings highlight C. cassia as a promising source of natural anti-obesity agents.
SN  - 1420-3049
ER  -