Long‐Term Effects of Myocardial Injury on 1‐Year Outcomes in Hospital Survivors With COVID‐19: A Prospective Cohort Study
- 1Division of Cardiology, Department of Internal Medicine, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
- 2Department of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
Abstract
Myocardial injury is both a common complication among hospitalized coronavirus disease 2019 (COVID‐19) patients and a major predictor of adverse clinical outcomes. However, its long‐term effects remain poorly defined. In this prospective cohort study of 2185 COVID‐19 survivors (531 with myocardial injury), we assessed 1‐year post‐discharge outcomes using Kaplan–Meier analysis and multivariable Cox regression before and after propensity score matching. Myocardial injury was associated with higher all‐cause mortality (adjusted hazard ratio [aHR] 3.14) and major adverse cardiovascular events (MACE) (aHR 5.22). Long‐term use of angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB) was associated with reduced mortality (aHR 0.44) and MACE (aHR 0.58) in the myocardial injury group. At 1 year, 71.5% of survivors reported persistent symptoms—most commonly fatigue and sleep difficulties—and those with myocardial injury had poorer quality of life. This study provides the prospective evidence from China's Omicron era on the prognostic value of myocardial injury, combining hard clinical endpoints with patient‐reported outcomes and the first analysis of the ACEI/ARB association in this population. These findings highlight the prognostic importance of myocardial injury and the potential role of ACEI/ARB therapy in post‐discharge management, supporting targeted follow‐up strategies for this high‐risk population.
Related
- Real-life Psychological Experiences and Subsequent Cardiovascular Events among Survivors of a Myocardial Infarction in Midlife: Prospective Cohort Study
- Clinical profile, risk factors and in-hospital outcomes of ST-segment elevation myocardial infarction in young versus older adults: a 5-year retrospective cohort study at a tertiary care centre in Riyadh, Saudi Arabia.
- Atrial and ventricular mechanical dysfunction and myocardial injury predict long-term outcomes in hypertrophic cardiomyopathy: a retrospective cohort study
- Association Between Platelet Count/Lactate Dehydrogenase Ratio and In-Hospital Mortality in the Patients With Sepsis-Induced Myocardial Injury
- Quality-of-Life and Weight Loss Outcomes Following an Individualized Nutrition and Physical Activity Counseling Program in Breast Cancer Survivors: A Prospective Single-Arm Pilot Study
BibTeX
@article{he2026longterm,
title = {{Long‐Term Effects of Myocardial Injury on 1‐Year Outcomes in Hospital Survivors With COVID‐19: A Prospective Cohort Study}},
author = {Wu He and Qiongyao He and Ke Xu and Gen Li and Yongcui Yan and Bo Yu and Yujing Su and Junfang Wu and Hong Wang and Dao Wen Wang},
journal = {MedComm},
year = {2026},
month = nov,
doi = {10.1002/mco2.71119},
url = {https://doi.org/10.1002/mco2.71119},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Long‐Term Effects of Myocardial Injury on 1‐Year Outcomes in Hospital Survivors With COVID‐19: A Prospective Cohort Study
AU - Wu He
AU - Qiongyao He
AU - Ke Xu
AU - Gen Li
AU - Yongcui Yan
AU - Bo Yu
AU - Yujing Su
AU - Junfang Wu
AU - Hong Wang
AU - Dao Wen Wang
PY - 2026
DA - 2026/11/03
JO - MedComm
DO - 10.1002/mco2.71119
UR - https://doi.org/10.1002/mco2.71119
AB - Myocardial injury is both a common complication among hospitalized coronavirus disease 2019 (COVID‐19) patients and a major predictor of adverse clinical outcomes. However, its long‐term effects remain poorly defined. In this prospective cohort study of 2185 COVID‐19 survivors (531 with myocardial injury), we assessed 1‐year post‐discharge outcomes using Kaplan–Meier analysis and multivariable Cox regression before and after propensity score matching. Myocardial injury was associated with higher all‐cause mortality (adjusted hazard ratio [aHR] 3.14) and major adverse cardiovascular events (MACE) (aHR 5.22). Long‐term use of angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB) was associated with reduced mortality (aHR 0.44) and MACE (aHR 0.58) in the myocardial injury group. At 1 year, 71.5% of survivors reported persistent symptoms—most commonly fatigue and sleep difficulties—and those with myocardial injury had poorer quality of life. This study provides the prospective evidence from China's Omicron era on the prognostic value of myocardial injury, combining hard clinical endpoints with patient‐reported outcomes and the first analysis of the ACEI/ARB association in this population. These findings highlight the prognostic importance of myocardial injury and the potential role of ACEI/ARB therapy in post‐discharge management, supporting targeted follow‐up strategies for this high‐risk population.
SN - 2688-2663
ER -