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Peer-reviewedCC BYAnnals of medicine

The potential of psychological intervention to decrease the risk of anxiety and depression in pulmonary fibrosis.

  • Eda Sara Persentili1
  • Mireia Baiges2
  • Marta Jiménez3
  • Miguel Sampayo-Cordero4
  • Yolanda Galea-Colon2
  • Raquel Cuevas1
  • Jaume Bordas-Martinez2,5
5 affiliations
  1. 1Psychology Department, Hospital General de Granollers, Granollers, Barcelona, Spain.
  2. 2Respiratory Department, Hospital General de Granollers, Granollers, Barcelona, Spain.
  3. 3Patient Experience Department, Hospital General de Granollers, Granollers, Barcelona, Spain.
  4. 4Research and Statistics Unit, Hospital General de Granollers, Granollers, Barcelona, Spain.
  5. 5Department of Medicine, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, Spain.
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Abstract

Background

Emotional distress in pulmonary fibrosis remains under-recognised and poorly addressed. This study assessed changes in anxiety and depressive symptoms following an individualised psychological intervention.Methods

Single-centre, single-arm before-and-after observational study of an individualised psychological intervention delivered in routine ILD care, combining acceptance and commitment therapy, humanistic-existential techniques, and psychophysiological interventions. Anxiety and depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS) before and after the intervention. Patient- and caregiver-reported experience measures (PREMs) were collected. Response was analysed across characteristics defined before any analysis of outcome data (age, sex, disease severity [ILD-GAP], frailty [CFS], time since diagnosis, and baseline HADS).Results

Thirty patients were included (50.0% women; mean age 71.0 years). At baseline, 76.7% scored ≥8 on HADS-anxiety and 76.7% on HADS-depression, indicatingclinically relevant symptom risk. Six patients discontinued (lung transplantation, palliative care, or death; n = 2 each). Among 24 evaluable patients, mean HADS-anxiety decreased from 11.3 to 6.6 (mean difference 4.7; 97.5% CI 2.6-6.9; p < 0.001) and HADS-depression from 10.7 to 5.5 (mean difference 5.2; 97.5% CI 3.2-7.2; p < 0.001). HADS-anxiety score improved in 19 patients, was unchanged in 3 and worsened in 2; HADS-depression score improved in 20, was unchanged in 2 and worsened in 2. No patient worsened in HADS category. No differences in response were detected by age, sex, disease severity, frailtyor time since diagnosis. Patient- and caregiver-reported experience scores were high (totalscore 9.4 [SD 0.7] in patients and 9.5 [SD 0.7] in caregivers).Conclusion

In this uncontrolled study, an individualised psychological intervention was associated with reduced anxiety and depressive symptoms and a lower proportion of patients at risk of clinically relevant anxiety and depression in pulmonary fibrosis. These findings suggest the potential of psychological care within routine ILD follow-up and require confirmation in randomised controlled trials.

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Cite

BibTeXRIS
BibTeX
@article{persentili2026potential,
  title = {{The potential of psychological intervention to decrease the risk of anxiety and depression in pulmonary fibrosis.}},
  author = {Eda Sara Persentili and Mireia Baiges and Marta Jiménez and Miguel Sampayo-Cordero and Yolanda Galea-Colon and Raquel Cuevas and Jaume Bordas-Martinez},
  journal = {Annals of medicine},
  year = {2026},
  month = oct,
  doi = {10.1080/07853890.2026.2743870},
  url = {https://europepmc.org/article/MED/42908336},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The potential of psychological intervention to decrease the risk of anxiety and depression in pulmonary fibrosis.
AU  - Eda Sara Persentili
AU  - Mireia Baiges
AU  - Marta Jiménez
AU  - Miguel Sampayo-Cordero
AU  - Yolanda Galea-Colon
AU  - Raquel Cuevas
AU  - Jaume Bordas-Martinez
PY  - 2026
DA  - 2026/10/22
JO  - Annals of medicine
DO  - 10.1080/07853890.2026.2743870
UR  - https://europepmc.org/article/MED/42908336
AB  - Background  Emotional distress in pulmonary fibrosis remains under-recognised and poorly addressed. This study assessed changes in anxiety and depressive symptoms following an individualised psychological intervention.Methods  Single-centre, single-arm before-and-after observational study of an individualised psychological intervention delivered in routine ILD care, combining acceptance and commitment therapy, humanistic-existential techniques, and psychophysiological interventions. Anxiety and depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS) before and after the intervention. Patient- and caregiver-reported experience measures (PREMs) were collected. Response was analysed across characteristics defined before any analysis of outcome data (age, sex, disease severity [ILD-GAP], frailty [CFS], time since diagnosis, and baseline HADS).Results  Thirty patients were included (50.0% women; mean age 71.0 years). At baseline, 76.7% scored ≥8 on HADS-anxiety and 76.7% on HADS-depression, indicatingclinically relevant symptom risk. Six patients discontinued (lung transplantation, palliative care, or death; n = 2 each). Among 24 evaluable patients, mean HADS-anxiety decreased from 11.3 to 6.6 (mean difference 4.7; 97.5% CI 2.6-6.9; p < 0.001) and HADS-depression from 10.7 to 5.5 (mean difference 5.2; 97.5% CI 3.2-7.2; p < 0.001). HADS-anxiety score improved in 19 patients, was unchanged in 3 and worsened in 2; HADS-depression score improved in 20, was unchanged in 2 and worsened in 2. No patient worsened in HADS category. No differences in response were detected by age, sex, disease severity, frailtyor time since diagnosis. Patient- and caregiver-reported experience scores were high (totalscore 9.4 [SD 0.7] in patients and 9.5 [SD 0.7] in caregivers).Conclusion  In this uncontrolled study, an individualised psychological intervention was associated with reduced anxiety and depressive symptoms and a lower proportion of patients at risk of clinically relevant anxiety and depression in pulmonary fibrosis. These findings suggest the potential of psychological care within routine ILD follow-up and require confirmation in randomised controlled trials.
SN  - 0785-3890
SN  - 1365-2060
ER  -