Multimodal phenotyping reveals plant-food-related dietary information in serum Raman spectra of community-dwelling Japanese adults
- 1University of Tsukuba
Abstract
Healthy dietary patterns are associated with long-term health, but diet-quality scores do not reveal how habitual dietary information is represented in human biological phenotypes. Here we linked habitual dietary assessment with preceding health records and contemporaneous clinical chemistry, serum metabolomics and serum Raman spectra in community-dwelling Japanese adults. Higher diet quality corresponded to a more favorable preceding health profile, but did not define discrete states across contemporary multivariate phenotypes. Instead, specific dietary information was recoverable across these layers: Raman spectra provided predictive information complementary to clinical and metabolomic measurements for multiple dietary variables. Raman variation corresponding to {beta}-carotene equivalent could be traced to carotenoid-assigned bands and aligned with a broader plant-food-related dietary dimension. These findings show that habitual diet is represented not as a single biological state but through biologically traceable dietary dimensions distributed across complementary phenotypic layers.
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BibTeX
@misc{hiraga2026multimodal,
title = {{Multimodal phenotyping reveals plant-food-related dietary information in serum Raman spectra of community-dwelling Japanese adults}},
author = {K. Hiraga and T. Miyamoto and T. Nishino and J. Yoon and K. Shibuya and X. Ye and T. Shi and W. Liu and H. Suzuki and H. Isoda and T. Sakurai and H. Nishiyama and T. Okura and M. Sekiya},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.08.754882},
url = {https://www.biorxiv.org/content/10.64898/2026.10.08.754882v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Multimodal phenotyping reveals plant-food-related dietary information in serum Raman spectra of community-dwelling Japanese adults
AU - K. Hiraga
AU - T. Miyamoto
AU - T. Nishino
AU - J. Yoon
AU - K. Shibuya
AU - X. Ye
AU - T. Shi
AU - W. Liu
AU - H. Suzuki
AU - H. Isoda
AU - T. Sakurai
AU - H. Nishiyama
AU - T. Okura
AU - M. Sekiya
PY - 2026
DA - 2026/10/08
PB - bioRxiv
DO - 10.64898/2026.10.08.754882
UR - https://www.biorxiv.org/content/10.64898/2026.10.08.754882v1
AB - Healthy dietary patterns are associated with long-term health, but diet-quality scores do not reveal how habitual dietary information is represented in human biological phenotypes. Here we linked habitual dietary assessment with preceding health records and contemporaneous clinical chemistry, serum metabolomics and serum Raman spectra in community-dwelling Japanese adults. Higher diet quality corresponded to a more favorable preceding health profile, but did not define discrete states across contemporary multivariate phenotypes. Instead, specific dietary information was recoverable across these layers: Raman spectra provided predictive information complementary to clinical and metabolomic measurements for multiple dietary variables. Raman variation corresponding to {beta}-carotene equivalent could be traced to carotenoid-assigned bands and aligned with a broader plant-food-related dietary dimension. These findings show that habitual diet is represented not as a single biological state but through biologically traceable dietary dimensions distributed across complementary phenotypic layers.
ER -