Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 2 min ago
Peer-reviewedCC BY-NC-ND 4.0Oncology Letters

PEG10/TRIB3 axis is associated with malignant behavior and Notch-related signaling in oral squamous cell carcinoma cells

  • Jing Zhang1
  • Ying Liu1,2
  1. 1Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
  2. 2Department of Stomatology, Guangdong Second Rongjun Youfu Hospital, Foshan, Guangdong 528200, P.R. China
Read full textPDFDOICite

Abstract

Oral squamous cell carcinoma (OSCC) is an aggressive oral epithelial neoplasm for which the expression of paternally expressed gene 10 (PEG10) has notable prognostic implications. However, the functional role of this protein in OSCC remains to be fully elucidated. The present study aimed to explore the function of PEG10 in regulating OSCC cell behavior and the potential mechanisms of this regulation. Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, wound healing and Transwell assays were employed to estimate cell proliferation, migration and invasion, respectively. Furthermore, flow cytometry assays were used to detect the cell cycle status and apoptosis of OSCC cells. Western blot analysis was used to examine the expression of PEG10 and Tribbles pseudokinase 3 (TRIB3), as well as cell cycle-, apoptosis- and Notch signaling-associated proteins. The HDOCK server (a hybrid docking server for protein and nucleic acid complex prediction) and co-immunoprecipitation assays were employed to investigate the relationship between PEG10 and TRIB3. The present study found PEG10 to be highly expressed in OSCC tissues and cells. PEG10 knockdown reduced cell proliferation, migration and invasion, arrested the cell cycle in the G0/G1 phase and stimulated apoptosis. TRIB3 expression was also shown to be elevated in OSCC cells and was decreased following PEG10 knockdown. Concurrent TRIB3 overexpression partially reversed the effects of PEG10 knockdown on malignant phenotypes and Notch-related protein expression. These findings suggested that the PEG10/TRIB3 axis may be associated with malignant behavior and Notch-related signaling in OSCC.

Related

  1. Role of podoplanin in tongue squamous cell carcinoma and the regulation of malignant cellular behaviors via the ERK/MMP-2 signaling axis
    Xiaowei Sheng, Liping Ding, Qiang Zhang +2
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  2. Vitamin D receptor is associated with farnesyl diphosphate synthase protein stability and malignant phenotypes in esophageal squamous cell carcinoma cells
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  3. TMSB10 marks a malignant epithelial programme spatially associated with fibroblast–matrix niches in oral squamous cell carcinoma
    Bizhu Yao, Yue Tang, Shixian Liu +3
    Frontiers in OncologyPeer-reviewedCC BY 4.0OncologyFrontiersCrossref
  4. VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways
    Yaru Zhang, Shuyao Wang, Zhipeng Zhao +3
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. LDHA Lactylation Drives Malignant Progression of Oral Squamous Cell Carcinoma via a Positive Feedback Loop with Lactate.
    Fan Song, Chen Hou, Yingzhao Huang +5
    International journal of biological sciencesPeer-reviewedCC BYFull textOncologyEurope PMC

Cite

BibTeXRIS
BibTeX
@article{zhang2026peg10trib3,
  title = {{PEG10/TRIB3 axis is associated with malignant behavior and Notch-related signaling in oral squamous cell carcinoma cells}},
  author = {Jing Zhang and Ying Liu},
  journal = {Oncology Letters},
  year = {2026},
  month = oct,
  doi = {10.3892/ol.2026.15914},
  url = {https://doi.org/10.3892/ol.2026.15914},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - PEG10/TRIB3 axis is associated with malignant behavior and Notch-related signaling in oral squamous cell carcinoma cells
AU  - Jing Zhang
AU  - Ying Liu
PY  - 2026
DA  - 2026/10/22
JO  - Oncology Letters
DO  - 10.3892/ol.2026.15914
UR  - https://doi.org/10.3892/ol.2026.15914
AB  - Oral squamous cell carcinoma (OSCC) is an aggressive oral epithelial neoplasm for which the expression of paternally expressed gene 10 (PEG10) has notable prognostic implications. However, the functional role of this protein in OSCC remains to be fully elucidated. The present study aimed to explore the function of PEG10 in regulating OSCC cell behavior and the potential mechanisms of this regulation. Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, wound healing and Transwell assays were employed to estimate cell proliferation, migration and invasion, respectively. Furthermore, flow cytometry assays were used to detect the cell cycle status and apoptosis of OSCC cells. Western blot analysis was used to examine the expression of PEG10 and Tribbles pseudokinase 3 (TRIB3), as well as cell cycle-, apoptosis- and Notch signaling-associated proteins. The HDOCK server (a hybrid docking server for protein and nucleic acid complex prediction) and co-immunoprecipitation assays were employed to investigate the relationship between PEG10 and TRIB3. The present study found PEG10 to be highly expressed in OSCC tissues and cells. PEG10 knockdown reduced cell proliferation, migration and invasion, arrested the cell cycle in the G0/G1 phase and stimulated apoptosis. TRIB3 expression was also shown to be elevated in OSCC cells and was decreased following PEG10 knockdown. Concurrent TRIB3 overexpression partially reversed the effects of PEG10 knockdown on malignant phenotypes and Notch-related protein expression. These findings suggested that the PEG10/TRIB3 axis may be associated with malignant behavior and Notch-related signaling in OSCC.
SN  - 1792-1074
SN  - 1792-1082
ER  -