Kinetics and specificity of orthoflaviviruses NS1 IgG after Zika virus infection in Yellow fever and dengue immunized individuals: a memory recall hypothesis
- 1Institut de Recherche Biomedicale des Armees
Abstract
Pre-existing Orthoflavivirus immunity can shape antibody recall upon infection with a heterologous virus. We monitored Zika virus (ZIKV) infection in individuals vaccinated against yellow fever virus (YFV), with or without prior dengue virus (DENV) exposure. We obtained longitudinal serology data (NS1- and whole-virus IgG responses) and neutralization titers on days 0 and 28 after ZIKV infection. YFV-neutralizing antibody levels remained stable over time, consistent with the long-lasting immunity induced by YFV vaccination. By contrast, ZIKV infection triggered an increase in anti-YFV NS1 IgG, suggesting a selective recall of YFV-specific memory B cells. A similar trend was observed for anti-DENV NS1 IgG exclusively in DENV-immune individuals. Thus, prior Orthoflavivirus exposure shapes the specificity and magnitude of NS1-directed humoral recall, with implications for serological interpretation.
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BibTeX
@misc{marquine2026kinetics,
title = {{Kinetics and specificity of orthoflaviviruses NS1 IgG after Zika virus infection in Yellow fever and dengue immunized individuals: a memory recall hypothesis}},
author = {S. Marquine and N. Ayhan and K. M. Meneyrol and E. Le Dault and S. Attoumani and E. Nurtop and G. Grard and A. Trignol and b. coutard and M. Mura and s. briolant and C. Badaut},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.10.26362723},
url = {https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Kinetics and specificity of orthoflaviviruses NS1 IgG after Zika virus infection in Yellow fever and dengue immunized individuals: a memory recall hypothesis
AU - S. Marquine
AU - N. Ayhan
AU - K. M. Meneyrol
AU - E. Le Dault
AU - S. Attoumani
AU - E. Nurtop
AU - G. Grard
AU - A. Trignol
AU - b. coutard
AU - M. Mura
AU - s. briolant
AU - C. Badaut
PY - 2026
DA - 2026/09/10
PB - medRxiv
DO - 10.64898/2026.09.10.26362723
UR - https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1
AB - Pre-existing Orthoflavivirus immunity can shape antibody recall upon infection with a heterologous virus. We monitored Zika virus (ZIKV) infection in individuals vaccinated against yellow fever virus (YFV), with or without prior dengue virus (DENV) exposure. We obtained longitudinal serology data (NS1- and whole-virus IgG responses) and neutralization titers on days 0 and 28 after ZIKV infection. YFV-neutralizing antibody levels remained stable over time, consistent with the long-lasting immunity induced by YFV vaccination. By contrast, ZIKV infection triggered an increase in anti-YFV NS1 IgG, suggesting a selective recall of YFV-specific memory B cells. A similar trend was observed for anti-DENV NS1 IgG exclusively in DENV-immune individuals. Thus, prior Orthoflavivirus exposure shapes the specificity and magnitude of NS1-directed humoral recall, with implications for serological interpretation.
ER -