Vasculitis Syndromes with Renal Involvement: A Review from a Case Series
Abstract
This review describes vasculitis syndromes that can be diagnosed by kidney biopsy. Microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) typically follow a rapidly progressive course, often leading to end-stage renal failure within a few months, with crescentic glomerulonephritis being the predominant finding on a kidney biopsy. However, some types primarily present with fever and elevated C-reactive protein levels, while the kidney function is preserved; in such cases, a kidney biopsy shows arteriolitis. Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophil infiltration and small-artery arteritis, and the renal prognosis is often favorable. Anti-glomerular basement membrane (GBM) glomerulonephritis is a hyperacute form of progressive glomerulonephritis that leads to end-stage renal failure within a few weeks, with most glomeruli exhibiting synchronous necrotizing glomerulitis. Among immune complex-mediated small-vessel vasculitides, many cases of IgA vasculitis correspond to IgA nephropathy; however, cases accompanied by endocapillary hypercellularity have also been observed.
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BibTeX
@article{ubara2026vasculitis,
title = {{Vasculitis Syndromes with Renal Involvement: A Review from a Case Series}},
author = {Yoshifumi Ubara and Kei Kono and Naoki Sawa},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7871-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7871-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Vasculitis Syndromes with Renal Involvement: A Review from a Case Series
AU - Yoshifumi Ubara
AU - Kei Kono
AU - Naoki Sawa
PY - 2026
DA - 2026/09/08
JO - Internal Medicine
DO - 10.2169/internalmedicine.7871-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7871-26/_article
AB - This review describes vasculitis syndromes that can be diagnosed by kidney biopsy. Microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) typically follow a rapidly progressive course, often leading to end-stage renal failure within a few months, with crescentic glomerulonephritis being the predominant finding on a kidney biopsy. However, some types primarily present with fever and elevated C-reactive protein levels, while the kidney function is preserved; in such cases, a kidney biopsy shows arteriolitis. Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophil infiltration and small-artery arteritis, and the renal prognosis is often favorable. Anti-glomerular basement membrane (GBM) glomerulonephritis is a hyperacute form of progressive glomerulonephritis that leads to end-stage renal failure within a few weeks, with most glomeruli exhibiting synchronous necrotizing glomerulitis. Among immune complex-mediated small-vessel vasculitides, many cases of IgA vasculitis correspond to IgA nephropathy; however, cases accompanied by endocapillary hypercellularity have also been observed.
SN - 1349-7235
SN - 0918-2918
ER -