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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Lens Capsule microRNA Profiling Across the Primary Angle-Closure Disease Spectrum: Association with Anterior Segment Crowding

  • Hae Min Park1,2
  • Hyun Soo Cho1
  • Yeji Yeon1
  • Min-Ji Cha1
  • Jong Sub Lee1,2
  • Soorack Ryu3
  • Jooyoung Yoon1,4
  • Yu Jeong Kim1,2,5
  • Won June Lee1,2
5 affiliations
  1. 1Department of Ophthalmology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
  2. 2Department of Ophthalmology, Hanyang University Seoul Hospital, Seoul 04763, Republic of Korea
  3. 3Department of Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
  4. 4Department of Ophthalmology, Hanyang University Guri Hospital, Guri 11923, Republic of Korea
  5. 5Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul 04763, Republic of Korea
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Abstract

We aimed to compare anterior lens capsule microRNA (miRNA) expression across the primary angle-closure disease (PACD) spectrum and a control group, and to examine associations between differentially expressed miRNAs and anterior segment biometric parameters. In this cross-sectional study, anterior lens capsule specimens were collected during cataract surgery from 27 eyes (seven controls, nine primary angle-closure suspect (PACS) eyes, six primary angle-closure (PAC) eyes, and five primary angle-closure glaucoma (PACG) eyes). The expression of 84 miRNAs was profiled, and the ΔCt values were compared across groups and correlated with anterior segment biometric parameters. Experimentally validated target genes of significant miRNAs were retrieved from miRTargetLink 2.0. miR-188-5p was the only miRNA that differed significantly between control and PACD eyes (control 11.27 ± 2.29 vs. PACD 8.21 ± 2.09; p = 0.003), with higher expression in PACS (p = 0.022) and PAC (p = 0.006). Higher miR-188-5p expression correlated with greater LV (r = −0.64, p = 0.033), narrower AOD500 (r = 0.50, p = 0.015), and shorter AXL (r = 0.41, p = 0.032). miR-146b-5p and miR-335-5p showed subgroup-specific differences and correlated with LV and AXL/AOD500, respectively, though these findings were exploratory. However, these findings did not remain significant after correction for multiple testing. Network analysis identified four experimentally validated targets of miR-188-5p (GREM2, ITGA7, CEMIP, FGF5) relevant to extracellular matrix turnover, hypoxia and inflammation. miR-188-5p was upregulated in the anterior lens capsule across the PACD spectrum and was associated with biometric hallmarks of a crowded anterior segment, suggesting its potential as a diagnostic or therapeutic candidate for PACD, pending validation in larger, functional studies.

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Cite

BibTeXRIS
BibTeX
@article{park2026lens,
  title = {{Lens Capsule microRNA Profiling Across the Primary Angle-Closure Disease Spectrum: Association with Anterior Segment Crowding}},
  author = {Hae Min Park and Hyun Soo Cho and Yeji Yeon and Min-Ji Cha and Jong Sub Lee and Soorack Ryu and Jooyoung Yoon and Yu Jeong Kim and Won June Lee},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27219556},
  url = {https://www.mdpi.com/1422-0067/27/21/9556},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Lens Capsule microRNA Profiling Across the Primary Angle-Closure Disease Spectrum: Association with Anterior Segment Crowding
AU  - Hae Min Park
AU  - Hyun Soo Cho
AU  - Yeji Yeon
AU  - Min-Ji Cha
AU  - Jong Sub Lee
AU  - Soorack Ryu
AU  - Jooyoung Yoon
AU  - Yu Jeong Kim
AU  - Won June Lee
PY  - 2026
DA  - 2026/10/26
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27219556
UR  - https://www.mdpi.com/1422-0067/27/21/9556
AB  - We aimed to compare anterior lens capsule microRNA (miRNA) expression across the primary angle-closure disease (PACD) spectrum and a control group, and to examine associations between differentially expressed miRNAs and anterior segment biometric parameters. In this cross-sectional study, anterior lens capsule specimens were collected during cataract surgery from 27 eyes (seven controls, nine primary angle-closure suspect (PACS) eyes, six primary angle-closure (PAC) eyes, and five primary angle-closure glaucoma (PACG) eyes). The expression of 84 miRNAs was profiled, and the ΔCt values were compared across groups and correlated with anterior segment biometric parameters. Experimentally validated target genes of significant miRNAs were retrieved from miRTargetLink 2.0. miR-188-5p was the only miRNA that differed significantly between control and PACD eyes (control 11.27 ± 2.29 vs. PACD 8.21 ± 2.09; p = 0.003), with higher expression in PACS (p = 0.022) and PAC (p = 0.006). Higher miR-188-5p expression correlated with greater LV (r = −0.64, p = 0.033), narrower AOD500 (r = 0.50, p = 0.015), and shorter AXL (r = 0.41, p = 0.032). miR-146b-5p and miR-335-5p showed subgroup-specific differences and correlated with LV and AXL/AOD500, respectively, though these findings were exploratory. However, these findings did not remain significant after correction for multiple testing. Network analysis identified four experimentally validated targets of miR-188-5p (GREM2, ITGA7, CEMIP, FGF5) relevant to extracellular matrix turnover, hypoxia and inflammation. miR-188-5p was upregulated in the anterior lens capsule across the PACD spectrum and was associated with biometric hallmarks of a crowded anterior segment, suggesting its potential as a diagnostic or therapeutic candidate for PACD, pending validation in larger, functional studies.
SN  - 1422-0067
ER  -