Chronic intermittent hypoxia triggers hepatic platelet recruitment
Abstract
Obstructive sleep apnea (OSA) and its landmark feature intermittent hypoxia (IH), is increasingly recognized as an independent risk factor for liver disease occurrence and progression. Yet, the early molecular events linking IH to hepatic injury remain poorly understood. Using a murine model of chronic IH, we identified a platelet-related transcriptional response in the liver, marked by the upregulation of genes involved in platelet activation, aggregation, and neutrophil degranulation. In the rodent model, histological analyses confirmed intrahepatic platelet accumulation and neutrophil infiltration as early stage preceding overt fibrosis or steatosis. Liver biopsies from OSA patients revealed increased staining for activated platelets, supporting the translational relevance of our findings. Collectively, our data identify intrahepatic platelet recruitment and activation as early and conserved features of the hepatic response to IH, pointing to platelet-neutrophil interactions as potential contributors to OSA-associated liver injury.
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BibTeX
@article{vial2026chronic,
title = {{Chronic intermittent hypoxia triggers hepatic platelet recruitment}},
author = {Guillaume Vial and Sophie Bouyon and Emilie Montellier and Florent Chuffart and Emeline Lemarie and Raoua Ben Messaoud and Marie Joyeux-Faure and Saadi Khochbin and Renaud Tamisier and Charlotte Costentin and Jean-Louis Pépin and Jonathan Gaucher},
journal = {Sleep Medicine},
year = {2026},
month = sep,
doi = {10.1016/j.sleep.2026.109049},
url = {https://hal.science/hal-05743849v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Chronic intermittent hypoxia triggers hepatic platelet recruitment
AU - Guillaume Vial
AU - Sophie Bouyon
AU - Emilie Montellier
AU - Florent Chuffart
AU - Emeline Lemarie
AU - Raoua Ben Messaoud
AU - Marie Joyeux-Faure
AU - Saadi Khochbin
AU - Renaud Tamisier
AU - Charlotte Costentin
AU - Jean-Louis Pépin
AU - Jonathan Gaucher
PY - 2026
DA - 2026/09/09
JO - Sleep Medicine
DO - 10.1016/j.sleep.2026.109049
UR - https://hal.science/hal-05743849v1
AB - Obstructive sleep apnea (OSA) and its landmark feature intermittent hypoxia (IH), is increasingly recognized as an independent risk factor for liver disease occurrence and progression. Yet, the early molecular events linking IH to hepatic injury remain poorly understood. Using a murine model of chronic IH, we identified a platelet-related transcriptional response in the liver, marked by the upregulation of genes involved in platelet activation, aggregation, and neutrophil degranulation. In the rodent model, histological analyses confirmed intrahepatic platelet accumulation and neutrophil infiltration as early stage preceding overt fibrosis or steatosis. Liver biopsies from OSA patients revealed increased staining for activated platelets, supporting the translational relevance of our findings. Collectively, our data identify intrahepatic platelet recruitment and activation as early and conserved features of the hepatic response to IH, pointing to platelet-neutrophil interactions as potential contributors to OSA-associated liver injury.
SN - 1389-9457
SN - 1878-5506
ER -