Somatic Programmed DNA Elimination is widespread in free-living Rhabditidae nematodes
Abstract
In this manuscript, the authors investigate programmed DNA elimination (PDE) across nematodes using a large-scale cytological approach. This work is potentially significant because it expands PDE beyond a few known nematodes to a much broader set of Rhabditidae species, providing an important resource for investigating PDE's evolutionary origins and functions. The strength of evidence, however, is incomplete; the technique used to evaluate PDE is insufficient to provide unambiguous support for the phenomenon, so additional methods, such as genomic sequencing from a few species spanning the range of elimination levels, would be required to confirm these findings. This research would be of interest to geneticists, evolutionary biologists, and those working on the regulation of genome integrity.
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BibTeX
@article{launay2026somatic,
title = {{Somatic Programmed DNA Elimination is widespread in free-living Rhabditidae nematodes}},
author = {Caroline Launay and Eva Wenger and Brice Letcher and Marie Delattre},
journal = {eLife},
year = {2026},
month = jun,
doi = {10.7554/elife.111501.1},
url = {https://hal.science/hal-05848138v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Somatic Programmed DNA Elimination is widespread in free-living Rhabditidae nematodes
AU - Caroline Launay
AU - Eva Wenger
AU - Brice Letcher
AU - Marie Delattre
PY - 2026
DA - 2026/06/03
JO - eLife
DO - 10.7554/elife.111501.1
UR - https://hal.science/hal-05848138v1
AB - In this manuscript, the authors investigate programmed DNA elimination (PDE) across nematodes using a large-scale cytological approach. This work is potentially significant because it expands PDE beyond a few known nematodes to a much broader set of Rhabditidae species, providing an important resource for investigating PDE's evolutionary origins and functions. The strength of evidence, however, is incomplete; the technique used to evaluate PDE is insufficient to provide unambiguous support for the phenomenon, so additional methods, such as genomic sequencing from a few species spanning the range of elimination levels, would be required to confirm these findings. This research would be of interest to geneticists, evolutionary biologists, and those working on the regulation of genome integrity.
SN - 2050-084X
ER -