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Peer-reviewedCC BY-NC-ND 4.0Clinical Epigenetics

Research progress and trends on epigenetics and endometriosis: a bibliometric analysis

  • Xiaohua Li1
  • Yiyun Bai1
  • Sang Luo2
  • Yiran Jin2
  • Junxian Yang1
  • Xiaxia An1
  • Dan Liu3,4,5
5 affiliations
  1. 1The First Clinical Medical College, Ningxia Medical University, Yinchuan 750004 Ningxia, China
  2. 2Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, 750004 Ningxia China
  3. 3Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004 China
  4. 4Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004 China
  5. 5Present Address: Department of Gynecology, General Hospital of Ningxia Medical University, No.692 Shengli Street, Xingqing District, Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750004 China
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Abstract

Background: Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics.

Methods: Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package “bibliometrix,” VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics.

Results: A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies.

Conclusions: This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13148-026-02220-y.

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Cite

BibTeXRIS
BibTeX
@article{li2026research,
  title = {{Research progress and trends on epigenetics and endometriosis: a bibliometric analysis}},
  author = {Xiaohua Li and Yiyun Bai and Sang Luo and Yiran Jin and Junxian Yang and Xiaxia An and Dan Liu},
  journal = {Clinical Epigenetics},
  year = {2026},
  month = aug,
  doi = {10.1186/s13148-026-02220-y},
  url = {https://doi.org/10.1186/s13148-026-02220-y},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Research progress and trends on epigenetics and endometriosis: a bibliometric analysis
AU  - Xiaohua Li
AU  - Yiyun Bai
AU  - Sang Luo
AU  - Yiran Jin
AU  - Junxian Yang
AU  - Xiaxia An
AU  - Dan Liu
PY  - 2026
DA  - 2026/08/03
JO  - Clinical Epigenetics
DO  - 10.1186/s13148-026-02220-y
UR  - https://doi.org/10.1186/s13148-026-02220-y
AB  - Background: Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics.  Methods: Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package “bibliometrix,” VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics.  Results: A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies.  Conclusions: This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13148-026-02220-y.
SN  - 1868-7075
SN  - 1868-7083
ER  -