Molecular recognition of glycosaminoglycans and their sulfated deep-sea bacteria-derived mimetics, diabolican…

Abstract

Maintenance of bone function and remodelling is a strictly controlled physiological process that is modulated by bone forming and resorbing, mediated by osteoblasts and osteoclasts respectively. A signalling axis involved in controlling this process involves receptor activator of nuclear factor kappa B ligand, receptor activator of nuclear factor kappa B and osteoprotegerin.

The two former proteins are vital in osteoclastogenesis whilst osteoprotegerin serves a modulatory role, interfering with the interaction of the other two proteins. The binding of these proteins by glycosaminoglycans has been identified, however the atomistic details are poorly understood. Here, compu

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BibTeX

@article{clark2026molecular,
  title = {{Molecular recognition of glycosaminoglycans and their sulfated deep-sea bacteria-derived mimetics, diabolican and infernan, by RANK, RANKL and OPG}},
  author = {Jacob A. Clark and Krzysztof Bojarski and Javier Muñoz-Garcia and Dominique Heymann and Sergey A. Samsonov},
  journal = {Carbohydrate Research},
  year = {2026},
  month = sep,
  url = {https://nantes-universite.hal.science/hal-05745586v1},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Molecular recognition of glycosaminoglycans and their sulfated deep-sea bacteria-derived mimetics, diabolican and infernan, by RANK, RANKL and OPG
AU  - Jacob A. Clark
AU  - Krzysztof Bojarski
AU  - Javier Muñoz-Garcia
AU  - Dominique Heymann
AU  - Sergey A. Samsonov
PY  - 2026
DA  - 2026/09/10
JO  - Carbohydrate Research
UR  - https://nantes-universite.hal.science/hal-05745586v1
AB  - Maintenance of bone function and remodelling is a strictly controlled physiological process that is modulated by bone forming and resorbing, mediated by osteoblasts and osteoclasts respectively. A signalling axis involved in controlling this process involves receptor activator of nuclear factor kappa B ligand, receptor activator of nuclear factor kappa B and osteoprotegerin.  The two former proteins are vital in osteoclastogenesis whilst osteoprotegerin serves a modulatory role, interfering with the interaction of the other two proteins. The binding of these proteins by glycosaminoglycans has been identified, however the atomistic details are poorly understood. Here, compu
SN  - 0008-6215
SN  - 0008-6215
ER  -

Abstract

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