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Peer-reviewedCC BY 4.0Stress Biology

Plant resilience: harnessing bioactive compounds for sustainable disease protection

  • Muhammad Zunair Latif1
  • Miaomiao Deng1
  • Naila Asghar2
  • Lingguang Kong1
  • Sumaira Kousar3
  • Haimiao Zhang1
  • Shams Ur Rehman4
  • Yanke Jiang1
  • Muhammad Humza1
  • ChongChong Lu1
  • Xinhua Ding1
4 affiliations
  1. 1State Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Tai’an, 271018 China
  2. 2College of Agronomy, Shandong Agricultural University, Tai’an, Shandong 271018 China
  3. 3Department of Biochemistry, Government College Women University, Faisalabad, 38000 Pakistan
  4. 4State Key Laboratory of Wheat Improvement, Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang, Weifang, Shandong 261325 China
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Abstract

Plants have evolved complex phytochemical and immune defense mechanisms in response to pathogen invasion. Plants deploy phytochemical defense system—signaling molecules, secondary metabolites, antimicrobial proteins and peptides—to mitigate the pathogens they encounter. Pathogens have developed strategies—effector proteins, efflux pumps and detoxification mechanisms—to manipulate or overcome plant defenses. This review offers insights into how these bioactive compounds are biosynthesized and activated following pathogen recognition. We provide an overview of the dynamic crosstalk between PTI and ETI and their role in optimizing plant defense. Additionally, we discuss the potential of advanced genetic engineering approaches, nanocarrier-mediated elicitor delivery, and microbiome engineering to enhance these natural defenses. Finally, we address the technical bottlenecks of engineering plant immunity and provide a roadmap for future research directions. This review provides a stronger mechanistic foundation for breeding crops with durable, broad-spectrum resilience for sustainable crop protection.

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Cite

BibTeXRIS
BibTeX
@article{latif2026plant,
  title = {{Plant resilience: harnessing bioactive compounds for sustainable disease protection}},
  author = {Muhammad Zunair Latif and Miaomiao Deng and Naila Asghar and Lingguang Kong and Sumaira Kousar and Haimiao Zhang and Shams Ur Rehman and Yanke Jiang and Muhammad Humza and ChongChong Lu and Xinhua Ding},
  journal = {Stress Biology},
  year = {2026},
  month = oct,
  doi = {10.1007/s44154-026-00343-z},
  url = {https://doi.org/10.1007/s44154-026-00343-z},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Plant resilience: harnessing bioactive compounds for sustainable disease protection
AU  - Muhammad Zunair Latif
AU  - Miaomiao Deng
AU  - Naila Asghar
AU  - Lingguang Kong
AU  - Sumaira Kousar
AU  - Haimiao Zhang
AU  - Shams Ur Rehman
AU  - Yanke Jiang
AU  - Muhammad Humza
AU  - ChongChong Lu
AU  - Xinhua Ding
PY  - 2026
DA  - 2026/10/26
JO  - Stress Biology
DO  - 10.1007/s44154-026-00343-z
UR  - https://doi.org/10.1007/s44154-026-00343-z
AB  - Plants have evolved complex phytochemical and immune defense mechanisms in response to pathogen invasion. Plants deploy phytochemical defense system—signaling molecules, secondary metabolites, antimicrobial proteins and peptides—to mitigate the pathogens they encounter. Pathogens have developed strategies—effector proteins, efflux pumps and detoxification mechanisms—to manipulate or overcome plant defenses. This review offers insights into how these bioactive compounds are biosynthesized and activated following pathogen recognition. We provide an overview of the dynamic crosstalk between PTI and ETI and their role in optimizing plant defense. Additionally, we discuss the potential of advanced genetic engineering approaches, nanocarrier-mediated elicitor delivery, and microbiome engineering to enhance these natural defenses. Finally, we address the technical bottlenecks of engineering plant immunity and provide a roadmap for future research directions. This review provides a stronger mechanistic foundation for breeding crops with durable, broad-spectrum resilience for sustainable crop protection.
SN  - 2097-4418
SN  - 2731-0450
ER  -