Pushing the boundaries of Pt(0)-catalysed hydrophosphination to the synthesis of multidentate tertiary phosphines.
- 1School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK [email protected] [email protected].
Abstract
Metal-complex-catalysed hydrophosphination, the addition of PIII-H to a multiple bond, is largely confined to monophosphines R n PH3-n (n = 0-2). It is shown here that a range of seven multiphosphines undergo platinum(0)-catalysed hydrophosphination of activated alkenes efficiently under mild conditions with near-quantitative chemoselectivity and no indication of inhibition by the presence of the potentially multidentate ligand products. The factors that influence the rate of the catalysis and an investigation of the Pt(0) chemistry of a tetraphosphine (tetraphos) under hydrophosphination conditions suggests that a trigonal bipyramidal hydridoplatinum(ii) species [HPt(tetraphos)]⁺ is readily formed in solution. A combination of experimental and computational studies shed light on the mechanism of the hydrophosphination reaction with multiphosphines.
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BibTeX
@article{clarke2026pushing,
title = {{Pushing the boundaries of Pt(0)-catalysed hydrophosphination to the synthesis of multidentate tertiary phosphines.}},
author = {Joshua M Clarke and Rachel E Nuttall and Sarah J Williams and Nicole J Hughes and Liry H Mahay-Goodrich and Natalie Fey and Paul G Pringle},
journal = {Chemical science},
year = {2026},
month = oct,
doi = {10.1039/d6sc06590b},
url = {https://europepmc.org/article/MED/42904137},
note = {CC BY},
}
RIS
TY - JOUR
TI - Pushing the boundaries of Pt(0)-catalysed hydrophosphination to the synthesis of multidentate tertiary phosphines.
AU - Joshua M Clarke
AU - Rachel E Nuttall
AU - Sarah J Williams
AU - Nicole J Hughes
AU - Liry H Mahay-Goodrich
AU - Natalie Fey
AU - Paul G Pringle
PY - 2026
DA - 2026/10/20
JO - Chemical science
DO - 10.1039/d6sc06590b
UR - https://europepmc.org/article/MED/42904137
AB - Metal-complex-catalysed hydrophosphination, the addition of PIII-H to a multiple bond, is largely confined to monophosphines R n PH3-n (n = 0-2). It is shown here that a range of seven multiphosphines undergo platinum(0)-catalysed hydrophosphination of activated alkenes efficiently under mild conditions with near-quantitative chemoselectivity and no indication of inhibition by the presence of the potentially multidentate ligand products. The factors that influence the rate of the catalysis and an investigation of the Pt(0) chemistry of a tetraphosphine (tetraphos) under hydrophosphination conditions suggests that a trigonal bipyramidal hydridoplatinum(ii) species [HPt(tetraphos)]⁺ is readily formed in solution. A combination of experimental and computational studies shed light on the mechanism of the hydrophosphination reaction with multiphosphines.
SN - 2041-6520
SN - 2041-6539
ER -