Stress Conditions Induced by Carvacrol and Cinnamaldehyde on Acinetobacter baumannii
Abstract
Acinetobacter baumannii has emerged as a major cause of nosocomial infections. The ability of A. baumannii to display various resistance mechanisms against antibiotics has transformed it into a successful nosocomial pathogen. The limited number of antibiotics in development and the disengagement of the pharmaceutical industry have prompted the development of innovative strategies. One of these strategies is the use of essential oils, especially aromatic compounds that are potent antibacterial molecules. Among them, the combination of carvacrol and cinnamaldehyde has already demonstrated antibacterial efficacy against A. baumannii. The aim of this study was to determine the biological effects of these two compounds in A. baumannii, describing their effect on the rRNA and gene regulation under environmental stress conditions. Results demonstrated rRNA degradation by the carvacrol/cinnamaldehyde mixture, and this effect was due to carvacrol. Degradation was conserved after encapsulation of the mixture in lipid nanocapsules. Results showed an upregulation of the genes coding for heat shock proteins, such as groES, groEL, dnaK, clpB, and the catalase katE, after exposure to carvacrol/cinnamaldehyde mixture. The catalase was upregulated after carvacrol exposure wich is related to an oxidative stress. The combination of thiourea (hydroxyl radical scavenger) and carvacrol demonstrated a potent bactericidal effect. These results underline the development of defense strategies of the bacteria by synthesis of reactive oxygen species in response to environmental stress conditions, such as carvacrol.
Related
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- Chemical stressors differentially induce prophage replication in Acinetobacter baumannii strains
- The large conjugative plasmid pAB3 integrates into the chromosome of Acinetobacter baumannii ATCC 17978
BibTeX
@article{montagu2026stress,
title = {{Stress Conditions Induced by Carvacrol and Cinnamaldehyde on Acinetobacter baumannii}},
author = {Angélique Montagu and Marie-Laure Joly-Guillou and Elisabeth Rossines and Jérôme Cayon and Marie Kempf and Patrick Saulnier},
journal = {Frontiers in Microbiology},
year = {2026},
month = sep,
doi = {10.3389/fmicb.2016.01133},
url = {https://hal.science/hal-01362226v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Stress Conditions Induced by Carvacrol and Cinnamaldehyde on Acinetobacter baumannii
AU - Angélique Montagu
AU - Marie-Laure Joly-Guillou
AU - Elisabeth Rossines
AU - Jérôme Cayon
AU - Marie Kempf
AU - Patrick Saulnier
PY - 2026
DA - 2026/09/18
JO - Frontiers in Microbiology
DO - 10.3389/fmicb.2016.01133
UR - https://hal.science/hal-01362226v1
AB - Acinetobacter baumannii has emerged as a major cause of nosocomial infections. The ability of A. baumannii to display various resistance mechanisms against antibiotics has transformed it into a successful nosocomial pathogen. The limited number of antibiotics in development and the disengagement of the pharmaceutical industry have prompted the development of innovative strategies. One of these strategies is the use of essential oils, especially aromatic compounds that are potent antibacterial molecules. Among them, the combination of carvacrol and cinnamaldehyde has already demonstrated antibacterial efficacy against A. baumannii. The aim of this study was to determine the biological effects of these two compounds in A. baumannii, describing their effect on the rRNA and gene regulation under environmental stress conditions. Results demonstrated rRNA degradation by the carvacrol/cinnamaldehyde mixture, and this effect was due to carvacrol. Degradation was conserved after encapsulation of the mixture in lipid nanocapsules. Results showed an upregulation of the genes coding for heat shock proteins, such as groES, groEL, dnaK, clpB, and the catalase katE, after exposure to carvacrol/cinnamaldehyde mixture. The catalase was upregulated after carvacrol exposure wich is related to an oxidative stress. The combination of thiourea (hydroxyl radical scavenger) and carvacrol demonstrated a potent bactericidal effect. These results underline the development of defense strategies of the bacteria by synthesis of reactive oxygen species in response to environmental stress conditions, such as carvacrol.
SN - 1664-302X
SN - 1664-302X
ER -