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Peer-reviewedCC BYBlood cancer journal

Socioeconomic deprivation does not affect survival outcomes in patients with mantle cell lymphoma: evidence from a German nationwide study.

  • Susanne von Kroge1
  • Sabrina Klotz2
  • Hanna Walk2
  • Carsten Bokemeyer2
  • Fabian Tetzlaff3
  • Henrik Kusche4
  • “LYSED” study group
  • Frederik Peters4
4 affiliations
  1. 1Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [email protected].
  2. 2Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  3. 3Division of Social Determinants of Health, Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
  4. 4Hamburg Cancer Registry, Ministry of Science, Research and Equality, Free and Hanseatic City of Hamburg, Hamburg, Germany.
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Abstract

Socioeconomic status (SES) is well recognized as an important determinant of cancer incidence and survival. However, its impact on outcomes in patients with mantle cell lymphoma (MCL) remains poorly characterized. We conducted a nationwide, population-based retrospective longitudinal study using German cancer registry data, including all patients diagnosed with MCL between 2013 and 2023. Regional SES was assessed annually at the district level using quintiles of the German Index of Socioeconomic Deprivation. The primary outcomes were 5-year absolute survival (AS) and relative survival (RS) as a proxy for disease-specific survival. A total of 8871 patients were included. Five-year AS and RS were 62.6% (95% CI, 61.5-63.7) and 72.1% (95% CI, 70.8-73.4), respectively. However, no meaningful differences in AS were observed between patients residing in districts of the lowest and highest SES quintiles (62.0% vs 63.1%). This nationwide population-based study indicates that regional socioeconomic deprivation was not associated with clinically relevant differences in survival outcomes among MCL patients in Germany between 2013 and 2023. These findings differ from previously described patterns in other lymphomas, suggesting that biological disease characteristics may exert a stronger influence on MCL survival than social determinants.

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Cite

BibTeXRIS
BibTeX
@article{kroge2026socioeconomic,
  title = {{Socioeconomic deprivation does not affect survival outcomes in patients with mantle cell lymphoma: evidence from a German nationwide study.}},
  author = {Susanne von Kroge and Sabrina Klotz and Hanna Walk and Carsten Bokemeyer and Fabian Tetzlaff and Henrik Kusche and “LYSED” study group and Frederik Peters},
  journal = {Blood cancer journal},
  year = {2026},
  month = oct,
  doi = {10.1038/s41408-026-01658-w},
  url = {https://europepmc.org/article/MED/42963359},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Socioeconomic deprivation does not affect survival outcomes in patients with mantle cell lymphoma: evidence from a German nationwide study.
AU  - Susanne von Kroge
AU  - Sabrina Klotz
AU  - Hanna Walk
AU  - Carsten Bokemeyer
AU  - Fabian Tetzlaff
AU  - Henrik Kusche
AU  - “LYSED” study group
AU  - Frederik Peters
PY  - 2026
DA  - 2026/10/30
JO  - Blood cancer journal
DO  - 10.1038/s41408-026-01658-w
UR  - https://europepmc.org/article/MED/42963359
AB  - Socioeconomic status (SES) is well recognized as an important determinant of cancer incidence and survival. However, its impact on outcomes in patients with mantle cell lymphoma (MCL) remains poorly characterized. We conducted a nationwide, population-based retrospective longitudinal study using German cancer registry data, including all patients diagnosed with MCL between 2013 and 2023. Regional SES was assessed annually at the district level using quintiles of the German Index of Socioeconomic Deprivation. The primary outcomes were 5-year absolute survival (AS) and relative survival (RS) as a proxy for disease-specific survival. A total of 8871 patients were included. Five-year AS and RS were 62.6% (95% CI, 61.5-63.7) and 72.1% (95% CI, 70.8-73.4), respectively. However, no meaningful differences in AS were observed between patients residing in districts of the lowest and highest SES quintiles (62.0% vs 63.1%). This nationwide population-based study indicates that regional socioeconomic deprivation was not associated with clinically relevant differences in survival outcomes among MCL patients in Germany between 2013 and 2023. These findings differ from previously described patterns in other lymphomas, suggesting that biological disease characteristics may exert a stronger influence on MCL survival than social determinants.
SN  - 2044-5385
ER  -