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Peer-reviewedCC BYChinese medicine

Modulating Th17-driven inflammation in ulcerative colitis with Chinese medicine: pathways, cytokines and beyond.

  • Yushi Tian1
  • Yuyi Yuan1
  • Zhiqiang Zhao1
  • Jingjing Li1
  • Gengchen Xue1
  • Jingbo Wang1
  • Shuangjiao Deng1
  • Heng Fan2
  • Yujin Liu3
  1. 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  2. 2Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [email protected].
  3. 3Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [email protected].
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Abstract

Ulcerative colitis (UC) is a type of chronic non-specific inflammation of the digestive tract, whose incidence is increasing gradually. Th17 cells and their cytokines play a critical role in the inflammatory response of UC. Th17 cells need a particular environment for the production of cytokines and exert their immunoregulatory functions. They promote inflammation and tissue healing and interact with other types of immune cells. The abundance of Th17 cells and their cytokine expression capability were found to significantly change in the intestines of patients with UC. In this paper, we discussed how traditional Chinese medicines (TCMs) regulate the function of Th17 cells and cytokine expression in UC. Chinese medicine monomers (e.g., matrine, paeoniflorin, curcumin, etc.) and compound decoctions (e.g., compound Sophorae decoction, Gegen Qinlian decoction, QingChang-XiaoPi decoction, etc.) were shown to regulate the behavior of Th17 cells and their cytokine capability by modulating several signaling pathways. These TCMs inhibited cytokine secretion, improved the intestinal bacterial flora, restored Th17/Treg cell balance, and alleviated intestinal inflammation. TCM offers a wide variety of molecules that modulate the Th17 response and the development of UC. The use of these molecules, in conjunction with conventional treatments, may provide a better therapeutic option for UC.

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Cite

BibTeXRIS
BibTeX
@article{tian2026modulating,
  title = {{Modulating Th17-driven inflammation in ulcerative colitis with Chinese medicine: pathways, cytokines and beyond.}},
  author = {Yushi Tian and Yuyi Yuan and Zhiqiang Zhao and Jingjing Li and Gengchen Xue and Jingbo Wang and Shuangjiao Deng and Heng Fan and Yujin Liu},
  journal = {Chinese medicine},
  year = {2026},
  month = oct,
  doi = {10.1186/s13020-026-01499-6},
  url = {https://europepmc.org/article/MED/42958293},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Modulating Th17-driven inflammation in ulcerative colitis with Chinese medicine: pathways, cytokines and beyond.
AU  - Yushi Tian
AU  - Yuyi Yuan
AU  - Zhiqiang Zhao
AU  - Jingjing Li
AU  - Gengchen Xue
AU  - Jingbo Wang
AU  - Shuangjiao Deng
AU  - Heng Fan
AU  - Yujin Liu
PY  - 2026
DA  - 2026/10/29
JO  - Chinese medicine
DO  - 10.1186/s13020-026-01499-6
UR  - https://europepmc.org/article/MED/42958293
AB  - Ulcerative colitis (UC) is a type of chronic non-specific inflammation of the digestive tract, whose incidence is increasing gradually. Th17 cells and their cytokines play a critical role in the inflammatory response of UC. Th17 cells need a particular environment for the production of cytokines and exert their immunoregulatory functions. They promote inflammation and tissue healing and interact with other types of immune cells. The abundance of Th17 cells and their cytokine expression capability were found to significantly change in the intestines of patients with UC. In this paper, we discussed how traditional Chinese medicines (TCMs) regulate the function of Th17 cells and cytokine expression in UC. Chinese medicine monomers (e.g., matrine, paeoniflorin, curcumin, etc.) and compound decoctions (e.g., compound Sophorae decoction, Gegen Qinlian decoction, QingChang-XiaoPi decoction, etc.) were shown to regulate the behavior of Th17 cells and their cytokine capability by modulating several signaling pathways. These TCMs inhibited cytokine secretion, improved the intestinal bacterial flora, restored Th17/Treg cell balance, and alleviated intestinal inflammation. TCM offers a wide variety of molecules that modulate the Th17 response and the development of UC. The use of these molecules, in conjunction with conventional treatments, may provide a better therapeutic option for UC.
SN  - 1749-8546
ER  -