Serum Fatty Acid Profiles Across Normoglycemia, Prediabetes, and Type 2 Diabetes: Associations with Glycemic and Cardiometabolic Parameters in a Kazakh Population
5 affiliations
- 1Kazakhstan-Japan Innovative Center, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan
- 2Institute of Genetic and Physiology, Almaty 050040, Kazakhstan
- 3Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan
- 4Department of Epidemiology and Biostatistics, Semey Medical University, Semey 071400, Kazakhstan
- 5Department of Propaedeutics of Internal Diseases, Semey Medical University, Semey 071400, Kazakhstan
Abstract
Population-specific data on serum fatty acids across the progression to type 2 diabetes mellitus (T2DM) are limited. In this exploratory cross-sectional study, serum fatty acids were determined by gas chromatography–mass spectrometry in 177 adults from Kazakhstan (45 normoglycemic, 114 with prediabetes, 18 with T2DM) and expressed as percentages of the quantified profile of the 13 components detected in ≥50% of samples. No fatty acid differed between glycemic groups after false discovery rate correction. In controls and participants with prediabetes, oleic and palmitoleic acids correlated with serum triglycerides (ρ = +0.65 and +0.32; q ≤ 0.005), and both associations persisted after adjustment for age, sex and adiposity and after exclusion of implausible profiles arising from a peak-assignment inconsistency. Across all participants, linoleic acid correlated inversely with glycated hemoglobin (HbA1c; ρ = −0.21, q = 0.033) in unadjusted analyses only. An association of heptadecanoic acid with HbA1c depended on its non-detection in part of the samples and was neither established nor excluded. Covariates were not recorded for the T2DM group, HbA1c was recorded with limited precision for most participants, and adjusted analyses were restricted to 107 participants without diabetes. The study describes serum fatty acid composition in this population and generates hypotheses.
Related
- Beyond associations: methodological and conceptual challenges in diet–microbiome research for cardiometabolic risk
- Meta-analysis of over 8,000 individuals from Hawai‘i and Samoa for genetic associations to cardiometabolic phenotypes
- Adiposity, Body Composition, and Cardiometabolic Outcomes in Women with and Without Gestational Diabetes
- Microbial Aromatic Amino Acid Metabolism in Cardiometabolic Disease
- Natural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives
BibTeX
@article{toishimanov2026serum,
title = {{Serum Fatty Acid Profiles Across Normoglycemia, Prediabetes, and Type 2 Diabetes: Associations with Glycemic and Cardiometabolic Parameters in a Kazakh Population}},
author = {Maxat Toishimanov and Aksholpan Shokan and Ivan Voitsekhovskiy and Bakyt Kanapiyanov and Nurgul Myrzabayeva and Alma Nurtazina},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219702},
url = {https://www.mdpi.com/1422-0067/27/21/9702},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Serum Fatty Acid Profiles Across Normoglycemia, Prediabetes, and Type 2 Diabetes: Associations with Glycemic and Cardiometabolic Parameters in a Kazakh Population
AU - Maxat Toishimanov
AU - Aksholpan Shokan
AU - Ivan Voitsekhovskiy
AU - Bakyt Kanapiyanov
AU - Nurgul Myrzabayeva
AU - Alma Nurtazina
PY - 2026
DA - 2026/10/29
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219702
UR - https://www.mdpi.com/1422-0067/27/21/9702
AB - Population-specific data on serum fatty acids across the progression to type 2 diabetes mellitus (T2DM) are limited. In this exploratory cross-sectional study, serum fatty acids were determined by gas chromatography–mass spectrometry in 177 adults from Kazakhstan (45 normoglycemic, 114 with prediabetes, 18 with T2DM) and expressed as percentages of the quantified profile of the 13 components detected in ≥50% of samples. No fatty acid differed between glycemic groups after false discovery rate correction. In controls and participants with prediabetes, oleic and palmitoleic acids correlated with serum triglycerides (ρ = +0.65 and +0.32; q ≤ 0.005), and both associations persisted after adjustment for age, sex and adiposity and after exclusion of implausible profiles arising from a peak-assignment inconsistency. Across all participants, linoleic acid correlated inversely with glycated hemoglobin (HbA1c; ρ = −0.21, q = 0.033) in unadjusted analyses only. An association of heptadecanoic acid with HbA1c depended on its non-detection in part of the samples and was neither established nor excluded. Covariates were not recorded for the T2DM group, HbA1c was recorded with limited precision for most participants, and adjusted analyses were restricted to 107 participants without diabetes. The study describes serum fatty acid composition in this population and generates hypotheses.
SN - 1422-0067
ER -