An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow
- 1Department of Otorhinolaryngology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, China; Guangdong Provincial Key Laboratory
Abstract
The cochlea lies within marrow-bearing bone. How this neighbouring marrow relates to cochlear immunity and daily physiology remains poorly resolved. We profiled 160,643 cells from mouse cochlea and adjacent temporal-bone marrow at six times of day, with rhythm inference calibrated for one pooled sample per time. Three-dimensional confocal reconstruction mapped vascular connections between marrow and cochlea and localized neutrophils along this interface. Neutrophils also occupied healthy cochlear fluids. Parabiosis findings were consistent with a local marrow contribution to cochlear immunity. Structural cochlear cells maintained synchronized, light-entrained clocks. Cochlear neutrophil programmes aligned with circulating neutrophils and opposed those in marrow, with independent flow cytometry supporting daily changes in immune composition and CXCR4. A shared night-associated heat-shock programme was attenuated after noise in an independent cohort. These anatomical and temporal data provide a reference for testing local marrow supply and the origins of cochlear immune rhythms.
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BibTeX
@misc{wang2026anatomical,
title = {{An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow}},
author = {H. Wang and J. Yeong and Y. Cai and Y. Mo and Y. Tian and W. Chen and D. Zeng and H. Ning and Y. Xu and S. Dai and X. Liu and R. He and H. Liu and J. Huang and J. Hao and Y. Ni and C. Tian},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.31.763358},
url = {https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow
AU - H. Wang
AU - J. Yeong
AU - Y. Cai
AU - Y. Mo
AU - Y. Tian
AU - W. Chen
AU - D. Zeng
AU - H. Ning
AU - Y. Xu
AU - S. Dai
AU - X. Liu
AU - R. He
AU - H. Liu
AU - J. Huang
AU - J. Hao
AU - Y. Ni
AU - C. Tian
PY - 2026
DA - 2026/10/31
PB - bioRxiv
DO - 10.64898/2026.10.31.763358
UR - https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1
AB - The cochlea lies within marrow-bearing bone. How this neighbouring marrow relates to cochlear immunity and daily physiology remains poorly resolved. We profiled 160,643 cells from mouse cochlea and adjacent temporal-bone marrow at six times of day, with rhythm inference calibrated for one pooled sample per time. Three-dimensional confocal reconstruction mapped vascular connections between marrow and cochlea and localized neutrophils along this interface. Neutrophils also occupied healthy cochlear fluids. Parabiosis findings were consistent with a local marrow contribution to cochlear immunity. Structural cochlear cells maintained synchronized, light-entrained clocks. Cochlear neutrophil programmes aligned with circulating neutrophils and opposed those in marrow, with independent flow cytometry supporting daily changes in immune composition and CXCR4. A shared night-associated heat-shock programme was attenuated after noise in an independent cohort. These anatomical and temporal data provide a reference for testing local marrow supply and the origins of cochlear immune rhythms.
ER -