Association Between Chronic Tamsulosin Therapy and Intraoperative Hemodynamics During Spinal Anesthesia: A Prospective Observational Study
- 1Department of Anesthesiology and Reanimation, İzmir City Hospital, İzmir 35530, Türkiye
- 2Department of Anesthesiology and Reanimation, Samsun City Hospital, Samsun 55080, Türkiye
- 3Department of Urology, İzmir Tepecik Training and Research Hospital, University of Health Sciences, İzmir 35180, Türkiye
Abstract
Background: This prospective observational study investigated the association between chronic tamsulosin therapy and intraoperative hemodynamic changes in patients undergoing elective transurethral resection of the prostate (TUR-P) under spinal anesthesia. Methods: Adult patients scheduled for elective TUR-P under spinal anesthesia were prospectively enrolled. Patients receiving long-term tamsulosin therapy comprised the tamsulosin group, whereas those with no history of α1-adrenergic blocker use served as the control group. Hemodynamic variables, including mean arterial pressure (MAP) and heart rate, were recorded before spinal anesthesia and at predefined time points during the first 60 min after spinal anesthesia. Results: A total of 115 patients were analyzed (tamsulosin, n = 56; control, n = 59). Baseline MAP was comparable between groups. The adjusted linear mixed-effects model demonstrated a significant group × time interaction for MAP (F(5, 565.10) = 8.34, p < 0.001). Adjusted between-group MAP differences were −4.9 mmHg (95% CI, −8.8 to −1.0; p = 0.015) at 5 min, −17.0 mmHg (95% CI, −20.2 to −13.8; p < 0.001) at 30 min, and −16.4 mmHg (95% CI, −19.5 to −13.3; p < 0.001) at 60 min. Criteria-defined hypotension occurred in 21/56 (37.5%) patients in the tamsulosin group and 17/59 (28.8%) in the control group (p = 0.32). Conclusions: Chronic tamsulosin therapy was associated with lower intraoperative MAP values during spinal anesthesia, without a statistically significant increase in the incidence of clinically defined hypotension. These findings suggest that chronic tamsulosin use may be associated with a different intraoperative blood pressure response following spinal anesthesia.
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BibTeX
@article{yoldas2026association,
title = {{Association Between Chronic Tamsulosin Therapy and Intraoperative Hemodynamics During Spinal Anesthesia: A Prospective Observational Study}},
author = {Tuba Kuvvet Yoldaş and Nevin Esra Gümüş and Aylin Ateşalp and Mehmet Yoldaş},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15207978},
url = {https://www.mdpi.com/2077-0383/15/20/7978},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association Between Chronic Tamsulosin Therapy and Intraoperative Hemodynamics During Spinal Anesthesia: A Prospective Observational Study
AU - Tuba Kuvvet Yoldaş
AU - Nevin Esra Gümüş
AU - Aylin Ateşalp
AU - Mehmet Yoldaş
PY - 2026
DA - 2026/10/01
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15207978
UR - https://www.mdpi.com/2077-0383/15/20/7978
AB - Background: This prospective observational study investigated the association between chronic tamsulosin therapy and intraoperative hemodynamic changes in patients undergoing elective transurethral resection of the prostate (TUR-P) under spinal anesthesia. Methods: Adult patients scheduled for elective TUR-P under spinal anesthesia were prospectively enrolled. Patients receiving long-term tamsulosin therapy comprised the tamsulosin group, whereas those with no history of α1-adrenergic blocker use served as the control group. Hemodynamic variables, including mean arterial pressure (MAP) and heart rate, were recorded before spinal anesthesia and at predefined time points during the first 60 min after spinal anesthesia. Results: A total of 115 patients were analyzed (tamsulosin, n = 56; control, n = 59). Baseline MAP was comparable between groups. The adjusted linear mixed-effects model demonstrated a significant group × time interaction for MAP (F(5, 565.10) = 8.34, p < 0.001). Adjusted between-group MAP differences were −4.9 mmHg (95% CI, −8.8 to −1.0; p = 0.015) at 5 min, −17.0 mmHg (95% CI, −20.2 to −13.8; p < 0.001) at 30 min, and −16.4 mmHg (95% CI, −19.5 to −13.3; p < 0.001) at 60 min. Criteria-defined hypotension occurred in 21/56 (37.5%) patients in the tamsulosin group and 17/59 (28.8%) in the control group (p = 0.32). Conclusions: Chronic tamsulosin therapy was associated with lower intraoperative MAP values during spinal anesthesia, without a statistically significant increase in the incidence of clinically defined hypotension. These findings suggest that chronic tamsulosin use may be associated with a different intraoperative blood pressure response following spinal anesthesia.
SN - 2077-0383
ER -