Nintedanib-induced Glomerular Microangiopathy after Long-term Nintedanib Administration Presenting with…

Abstract

We herein report a rare case of nintedanib-induced glomerular microangiopathy (GMA) in a 77-year-old woman with idiopathic pulmonary fibrosis. The patient developed nephrotic-range proteinuria (5.9 g/gCr) after 29 months of nintedanib therapy. A kidney biopsy confirmed GMA, which was characterized by endothelial injury without immune complex deposition. The discontinuation of nintedanib led to a significant reduction in proteinuria. This case demonstrates that nintedanib-induced GMA can manifest after long-term use. Given the potential for a global underdiagnosis, regular urinalysis testing is therefore essential for the early detection of irreversible renal damage, particularly in elderly patients.

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BibTeX RIS

BibTeX

@article{watada2026nintedanibinduced,
  title = {{Nintedanib-induced Glomerular Microangiopathy after Long-term Nintedanib Administration Presenting with Nephrotic Syndrome}},
  author = {Mizuki Watada and Yurina Yataka and Motoki Hoshino and Wakana Shoda and Tamaki Kuyama and Kiyotaka Nagahama and Daiei Takahashi},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6981-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6981-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Nintedanib-induced Glomerular Microangiopathy after Long-term Nintedanib Administration Presenting with Nephrotic Syndrome
AU  - Mizuki Watada
AU  - Yurina Yataka
AU  - Motoki Hoshino
AU  - Wakana Shoda
AU  - Tamaki Kuyama
AU  - Kiyotaka Nagahama
AU  - Daiei Takahashi
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6981-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6981-25/_article
AB  - We herein report a rare case of nintedanib-induced glomerular microangiopathy (GMA) in a 77-year-old woman with idiopathic pulmonary fibrosis. The patient developed nephrotic-range proteinuria (5.9 g/gCr) after 29 months of nintedanib therapy. A kidney biopsy confirmed GMA, which was characterized by endothelial injury without immune complex deposition. The discontinuation of nintedanib led to a significant reduction in proteinuria. This case demonstrates that nintedanib-induced GMA can manifest after long-term use. Given the potential for a global underdiagnosis, regular urinalysis testing is therefore essential for the early detection of irreversible renal damage, particularly in elderly patients.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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