Enhancing food digestion and nutrient absorption through pre-digestion: Tailored strategies for special populations
Abstract
The human body relies on the intake and utilization of nutrients from food to support growth, development, and daily activities. However, certain groups, such as infants, the elderly, and patients with digestive diseases (e.g., chronic atrophic gastritis, pancreatitis, and cystic fibrosis) experience impaired gastrointestinal function due to developmental immaturity or physiological decline, leading to reduced digestion and absorption capacity. This has resulted in the emergence of pre-digested foods. Nonetheless, research on the nutritional and functional properties of these foods, specifically tailored to the gastrointestinal characteristics of these special populations, remains limited. This review begins with an overview of the general processes of digestion, absorption, and fermentation in the human digestive tract. It then summarizes the physiological characteristics of the gastrointestinal systems in infants, the elderly, and individuals with digestive diseases, while highlighting recent advancements regarding the effects of food pre-digestion on the digestive and absorption capabilities of these groups. The insights presented aim to provide a scientific foundation for the precise design and development of healthy foods suited for these populations.
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BibTeX
@article{wu2026enhancing,
title = {{Enhancing food digestion and nutrient absorption through pre-digestion: Tailored strategies for special populations}},
author = {Peng Wu and Shao-Xiu Pu and Mao-Shuai Jiang and Ze-Jun Hu and Chang-Yong Li and Didier Dupont and Xiao-Dong Chen},
journal = {Food \& Medicine Homology},
year = {2026},
month = oct,
doi = {10.26599/fmh.2025.9420069},
url = {https://hal.inrae.fr/hal-05780702v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Enhancing food digestion and nutrient absorption through pre-digestion: Tailored strategies for special populations
AU - Peng Wu
AU - Shao-Xiu Pu
AU - Mao-Shuai Jiang
AU - Ze-Jun Hu
AU - Chang-Yong Li
AU - Didier Dupont
AU - Xiao-Dong Chen
PY - 2026
DA - 2026/10/06
JO - Food & Medicine Homology
DO - 10.26599/fmh.2025.9420069
UR - https://hal.inrae.fr/hal-05780702v1
AB - The human body relies on the intake and utilization of nutrients from food to support growth, development, and daily activities. However, certain groups, such as infants, the elderly, and patients with digestive diseases (e.g., chronic atrophic gastritis, pancreatitis, and cystic fibrosis) experience impaired gastrointestinal function due to developmental immaturity or physiological decline, leading to reduced digestion and absorption capacity. This has resulted in the emergence of pre-digested foods. Nonetheless, research on the nutritional and functional properties of these foods, specifically tailored to the gastrointestinal characteristics of these special populations, remains limited. This review begins with an overview of the general processes of digestion, absorption, and fermentation in the human digestive tract. It then summarizes the physiological characteristics of the gastrointestinal systems in infants, the elderly, and individuals with digestive diseases, while highlighting recent advancements regarding the effects of food pre-digestion on the digestive and absorption capabilities of these groups. The insights presented aim to provide a scientific foundation for the precise design and development of healthy foods suited for these populations.
SN - 3006-6867
SN - 3006-4252
ER -