Chemical composition and antioxidant properties of selected mangrove species from the Sine Saloum Delta (Senegal) using UHPLC-MS/MS and molecular networking
Abstract
Mangrove ecosystems are important sources of secondary metabolites with significant pharmacological potential. However, the chemical diversity of West African mangroves remains largely unexplored. This study investigated the phytochemical composition and antioxidant activity of aqueous and hydroethanolic extracts from Avicennia germinans, Laguncularia racemosa, and Conocarpus erectus leaves, harvested from the Sine Saloum Delta Biosphere Reserve (Senegal). Metabolic profiling was performed by UHPLC-MS/MS combined with Feature-Based Molecular Networking (FBMN) for metabolite annotation. Antioxidant activity was assessed by off-line and on-line DPPH and ABTS assays, while the total phenolic content (TPC) was determined by the Folin-Ciocalteu method. A total of 153 metabolites were tentatively annotated, primarily phenolic acids, flavonoids, hydrolysable tannins and terpenoids. L. racemosa and C. erectus exhibited the highest TPC and the strongest antioxidant activities, while A. germinans showed limited free radical scavenging activity despite its high triterpenoid content. On-line UHPLC-DPPH/ABTS-MS/MS analysis enabled the rapid identification of the main antioxidant metabolites such as ellagic acid, myricetin and quercetin glycosides. This metabolomics approach highlights the chemical richness and antioxidant potential of L. racemosa and C. erectus. This study contributes to the chemical characterization and valorization of Senegalese mangroves as promising sources of bioactive natural products.
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BibTeX
@article{gaye2026chemical,
title = {{Chemical composition and antioxidant properties of selected mangrove species from the Sine Saloum Delta (Senegal) using UHPLC-MS/MS and molecular networking}},
author = {Cheikhouna Gaye and Elnur Garayev and Yoro Tine and Fathi Mabrouki and Myriam Bertolotti and Charifat Saïd Hassane and Sok-Siya Bun-Llopet and Djibril Fall and Anne Bousquet-Mélou and Béatrice Baghdikian},
journal = {Scientific Reports},
year = {2026},
month = jun,
doi = {10.1038/s41598-026-59275-3},
url = {https://hal.science/hal-05761657v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Chemical composition and antioxidant properties of selected mangrove species from the Sine Saloum Delta (Senegal) using UHPLC-MS/MS and molecular networking
AU - Cheikhouna Gaye
AU - Elnur Garayev
AU - Yoro Tine
AU - Fathi Mabrouki
AU - Myriam Bertolotti
AU - Charifat Saïd Hassane
AU - Sok-Siya Bun-Llopet
AU - Djibril Fall
AU - Anne Bousquet-Mélou
AU - Béatrice Baghdikian
PY - 2026
DA - 2026/06/23
JO - Scientific Reports
DO - 10.1038/s41598-026-59275-3
UR - https://hal.science/hal-05761657v1
AB - Mangrove ecosystems are important sources of secondary metabolites with significant pharmacological potential. However, the chemical diversity of West African mangroves remains largely unexplored. This study investigated the phytochemical composition and antioxidant activity of aqueous and hydroethanolic extracts from Avicennia germinans, Laguncularia racemosa, and Conocarpus erectus leaves, harvested from the Sine Saloum Delta Biosphere Reserve (Senegal). Metabolic profiling was performed by UHPLC-MS/MS combined with Feature-Based Molecular Networking (FBMN) for metabolite annotation. Antioxidant activity was assessed by off-line and on-line DPPH and ABTS assays, while the total phenolic content (TPC) was determined by the Folin-Ciocalteu method. A total of 153 metabolites were tentatively annotated, primarily phenolic acids, flavonoids, hydrolysable tannins and terpenoids. L. racemosa and C. erectus exhibited the highest TPC and the strongest antioxidant activities, while A. germinans showed limited free radical scavenging activity despite its high triterpenoid content. On-line UHPLC-DPPH/ABTS-MS/MS analysis enabled the rapid identification of the main antioxidant metabolites such as ellagic acid, myricetin and quercetin glycosides. This metabolomics approach highlights the chemical richness and antioxidant potential of L. racemosa and C. erectus. This study contributes to the chemical characterization and valorization of Senegalese mangroves as promising sources of bioactive natural products.
SN - 2045-2322
ER -