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PreprintCC BY-NC-NDbioRxiv

Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination

  • Jacquelyn Weaver1,2
  • John Houck1
  • Yonghou Jiang1
  • Cara Tobey1,3
  • Jia Wong3
  • Swati Shree3
  • Whitney E Harrington1,4,5
5 affiliations
  1. 1Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA
  2. 2Institute for Public Health Genetics, University of Washington School of Public Health, Seattle, WA
  3. 3Department of Obstetrics & Gynecology, University of Washington School of Medicine, Seattle, WA
  4. 4Department of Pediatrics, University of Washington School of Medicine, Seattle, WA
  5. 5Department of Global Health, University of Washington, Seattle, WA
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Abstract

The fetus acquires a graft of maternal cells in utero, known as maternal microchimerism (MMc), which may be enriched for T cells. However, little is known regarding the determinants of T cell trafficking into the fetus or regarding the prevalence of T cell MMc in healthy neonates. Using a closely followed cohort, we determined the association between maternal vaccination and acute infection and the detection of T cell MMc in cord blood, as measured using polymorphism-specific qPCR. We identified an association between early pregnancy SARS2 mRNA vaccination, a potent T cell stimulus, and increased detection of T cell MMc.

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Cite

BibTeXRIS
BibTeX
@misc{weaver2026neonatal,
  title = {{Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination}},
  author = {Jacquelyn Weaver and John Houck and Yonghou Jiang and Cara Tobey and Jia Wong and Swati Shree and Whitney E Harrington},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.23.761412},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination
AU  - Jacquelyn Weaver
AU  - John Houck
AU  - Yonghou Jiang
AU  - Cara Tobey
AU  - Jia Wong
AU  - Swati Shree
AU  - Whitney E Harrington
PY  - 2026
DA  - 2026/10/23
PB  - bioRxiv
DO  - 10.64898/2026.10.23.761412
UR  - https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1
AB  - The fetus acquires a graft of maternal cells in utero, known as maternal microchimerism (MMc), which may be enriched for T cells. However, little is known regarding the determinants of T cell trafficking into the fetus or regarding the prevalence of T cell MMc in healthy neonates. Using a closely followed cohort, we determined the association between maternal vaccination and acute infection and the detection of T cell MMc in cord blood, as measured using polymorphism-specific qPCR. We identified an association between early pregnancy SARS2 mRNA vaccination, a potent T cell stimulus, and increased detection of T cell MMc.
SN  - 2692-8205
ER  -