Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity
4 affiliations
- 1Centre for Food, Food Security and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon
- 2Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaoundé, Cameroon
- 3Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon
- 4Department of Biotechnology and Food Technology, University of Johannesburg, Johannesburg, South Africa
Abstract
Obesity contributes to increased morbidity and mortality, yet its metabolic heterogeneity remains underexplored in sub-Saharan Africa. This study examined associations between body composition, insulin sensitivity, inflammation, and the metabolically healthy profile (MHP), and assessed cardiovascular risk among Cameroonian adults with and without obesity. In this cross-sectional study, 490 participants from the West region of Cameroon underwent anthropometric and metabolic assessments. Ten-year cardiovascular risk was estimated using the Framingham risk score. Logistic regression identified predictors of MHP and determinants of elevated cardiovascular risk. The prevalence of MHP was 59.6% among individuals with normal weight, 11.5% among those with overweight, and 38.2% among those with obesity. Participants with overweight, obesity, android obesity or insulin resistance were 92%, 59%, 58%, and 46% less likely to have a MHP than participants in the control groups, respectively. Inflammation defined solely by CRP-hs was not predictive. Compared with metabolically unhealthy counterparts, metabolically healthy obese (OR = 6.27; 95% CI: 3.15-12.48) and overweight (OR = 2.50; 95% CI: 0.72-8.65) individuals had substantially lower predicted 10-year cardiovascular risk. Metabolic phenotyping reveals that not all Cameroonians with overweight and obesity present the same cardiovascular risk. Incorporating fat distribution and insulin sensitivity into clinical evaluation could improve early identification of high-risk individuals and guide tailored prevention strategies.
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BibTeX
@article{nguedjo2026metabolic,
title = {{Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity}},
author = {Maxwell Wandji Nguedjo and Ousmane Mfopou Mbiondi and Kevin Fabrice Paul Mandeng and Alex Dimitri Tchuenchieu Kamgain and Gabriel Nama Medoua and Judith Laure Ngondi and Julius Enyong Oben},
journal = {PLOS Global Public Health},
year = {2026},
month = sep,
doi = {10.1371/journal.pgph.0006870},
url = {https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006870},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity
AU - Maxwell Wandji Nguedjo
AU - Ousmane Mfopou Mbiondi
AU - Kevin Fabrice Paul Mandeng
AU - Alex Dimitri Tchuenchieu Kamgain
AU - Gabriel Nama Medoua
AU - Judith Laure Ngondi
AU - Julius Enyong Oben
PY - 2026
DA - 2026/09/23
JO - PLOS Global Public Health
DO - 10.1371/journal.pgph.0006870
UR - https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006870
AB - Obesity contributes to increased morbidity and mortality, yet its metabolic heterogeneity remains underexplored in sub-Saharan Africa. This study examined associations between body composition, insulin sensitivity, inflammation, and the metabolically healthy profile (MHP), and assessed cardiovascular risk among Cameroonian adults with and without obesity. In this cross-sectional study, 490 participants from the West region of Cameroon underwent anthropometric and metabolic assessments. Ten-year cardiovascular risk was estimated using the Framingham risk score. Logistic regression identified predictors of MHP and determinants of elevated cardiovascular risk. The prevalence of MHP was 59.6% among individuals with normal weight, 11.5% among those with overweight, and 38.2% among those with obesity. Participants with overweight, obesity, android obesity or insulin resistance were 92%, 59%, 58%, and 46% less likely to have a MHP than participants in the control groups, respectively. Inflammation defined solely by CRP-hs was not predictive. Compared with metabolically unhealthy counterparts, metabolically healthy obese (OR = 6.27; 95% CI: 3.15-12.48) and overweight (OR = 2.50; 95% CI: 0.72-8.65) individuals had substantially lower predicted 10-year cardiovascular risk. Metabolic phenotyping reveals that not all Cameroonians with overweight and obesity present the same cardiovascular risk. Incorporating fat distribution and insulin sensitivity into clinical evaluation could improve early identification of high-risk individuals and guide tailored prevention strategies.
SN - 2767-3375
ER -