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Peer-reviewedCC BY-NC-NDEJNMMI reports

Central and peripheral Neurolymphomatosis, a rare involvement of DLBCL on PET/CT.

  • Febby Hutomo1
  • Ivana Dewi Mulyanto1
  • Hapsari Indrawati1
  • Edelyn Christina1
  • Elizabeth Celine1
  • Marcel P M Stokkel2
  1. 1Department of Nuclear Medicine, MRCCC SILOAM Hospitals Semanggi, Jakarta, Indonesia.
  2. 2Department of Nuclear Medicine, Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Plesmanlaan 121, Amsterdam, 1066 CX, Kingdom of the Netherlands. [email protected].
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Abstract

In this paper we present two rare cases of patients suffering from diffuse large B-cell lymphoma initially treated with chemotherapy. During follow-up, they presented with central and peripheral neurological symptoms, respectively. On PET/CT, intense uptake of FDG was seen indicating neurolymphomatosis. Because of the localization it was not possible to take a biopsy for histological examination, but clinicians relied on imaging, clinical course and laboratory tests for a final diagnosis. Both patients died shortly after this examination underlining the poor prognosis of neurolymphomatosis.

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Cite

BibTeXRIS
BibTeX
@article{hutomo2026central,
  title = {{Central and peripheral Neurolymphomatosis, a rare involvement of DLBCL on PET/CT.}},
  author = {Febby Hutomo and Ivana Dewi Mulyanto and Hapsari Indrawati and Edelyn Christina and Elizabeth Celine and Marcel P M Stokkel},
  journal = {EJNMMI reports},
  year = {2026},
  month = nov,
  doi = {10.1186/s41824-026-00335-2},
  url = {https://europepmc.org/article/MED/42967972},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Central and peripheral Neurolymphomatosis, a rare involvement of DLBCL on PET/CT.
AU  - Febby Hutomo
AU  - Ivana Dewi Mulyanto
AU  - Hapsari Indrawati
AU  - Edelyn Christina
AU  - Elizabeth Celine
AU  - Marcel P M Stokkel
PY  - 2026
DA  - 2026/11/02
JO  - EJNMMI reports
DO  - 10.1186/s41824-026-00335-2
UR  - https://europepmc.org/article/MED/42967972
AB  - In this paper we present two rare cases of patients suffering from diffuse large B-cell lymphoma initially treated with chemotherapy. During follow-up, they presented with central and peripheral neurological symptoms, respectively. On PET/CT, intense uptake of FDG was seen indicating neurolymphomatosis. Because of the localization it was not possible to take a biopsy for histological examination, but clinicians relied on imaging, clinical course and laboratory tests for a final diagnosis. Both patients died shortly after this examination underlining the poor prognosis of neurolymphomatosis.
SN  - 3005-074X
ER  -