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Peer-reviewedCC BY-NC-ND 4.0The Journal of Laryngology and Otology

Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison

  • Aviv Yvonne Segal1
  • Basem Hijazi1
  • Ohad Ronen1,2
  1. 1Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel
  2. 2Department of Otolaryngology - Head and Neck Surgery, Galilee Medical Centre, Nahariya, Israel
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Abstract

Objectives: Juvenile nasopharyngeal angiofibroma is a highly vascular benign tumour affecting adolescent males. Our aim was to compare operative outcomes in embolised and non-embolised patients, with emphasis on tumour stage.

Methods: A systematic review was conducted using three databases (PubMed, Scopus and Google Scholar) in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.

Results: Overall, 17 studies with a total of 524 patients met the inclusion criteria. The meta-analysis showed a significant difference in estimated blood loss between embolised and non-embolised groups (overall effect size -685 ml; p < 0.001). Additionally, embolised patients with advanced stage tumours tended to lose less blood during surgery than non-embolised patients (mean of 1551.9 ml vs. 4051.5 ml; p = 0.065).

Conclusion: This systematic review and meta-analysis demonstrate that pre-operative endovascular embolisation provides an operative advantage in patients undergoing juvenile nasopharyngeal angiofibroma surgical resection. A near-significant trend towards greater benefit in higher-stage tumours was observed (p = 0.065), warranting further prospective investigation.

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Cite

BibTeXRIS
BibTeX
@article{segal2026operative,
  title = {{Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison}},
  author = {Aviv Yvonne Segal and Basem Hijazi and Ohad Ronen},
  journal = {The Journal of Laryngology and Otology},
  year = {2026},
  month = oct,
  doi = {10.1017/s0022215126104885},
  url = {https://doi.org/10.1017/s0022215126104885},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison
AU  - Aviv Yvonne Segal
AU  - Basem Hijazi
AU  - Ohad Ronen
PY  - 2026
DA  - 2026/10/30
JO  - The Journal of Laryngology and Otology
DO  - 10.1017/s0022215126104885
UR  - https://doi.org/10.1017/s0022215126104885
AB  - Objectives: Juvenile nasopharyngeal angiofibroma is a highly vascular benign tumour affecting adolescent males. Our aim was to compare operative outcomes in embolised and non-embolised patients, with emphasis on tumour stage.  Methods: A systematic review was conducted using three databases (PubMed, Scopus and Google Scholar) in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.  Results: Overall, 17 studies with a total of 524 patients met the inclusion criteria. The meta-analysis showed a significant difference in estimated blood loss between embolised and non-embolised groups (overall effect size -685 ml; p < 0.001). Additionally, embolised patients with advanced stage tumours tended to lose less blood during surgery than non-embolised patients (mean of 1551.9 ml vs. 4051.5 ml; p = 0.065).  Conclusion: This systematic review and meta-analysis demonstrate that pre-operative endovascular embolisation provides an operative advantage in patients undergoing juvenile nasopharyngeal angiofibroma surgical resection. A near-significant trend towards greater benefit in higher-stage tumours was observed (p = 0.065), warranting further prospective investigation.
SN  - 0022-2151
SN  - 1748-5460
ER  -