Associations of lipid-related parameters and indices with TSH-defined hypothyroid status in patients with Hashimoto’s thyroiditis: a retrospective cross-sectional study
- 1Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University
- 2The First Clinical College, Zhengzhou University
Abstract
Objective: To examine the associations of eight lipid-related parameters and indices with thyroid-stimulating hormone (TSH)-defined hypothyroid status in patients with Hashimoto’s thyroiditis (HT).
Methods: This retrospective cross-sectional study included 422 patients with HT. Hypothyroid status was defined as TSH ≥4.5 mIU/L. Associations were estimated using multivariable logistic regression adjusted for age, sex, and laboratory-derived diabetes status. Secondary analyses distinguished non-hypothyroid status, a subclinical hypothyroid pattern, and an overt hypothyroid pattern according to TSH and free thyroxine levels, and analyzed TSH as a continuous outcome. P values were adjusted using the Benjamini-Hochberg false discovery rate procedure.
Results: Among the 422 patients, 221 had TSH-defined hypothyroid status and 201 had non-hypothyroid status. All eight parameters and indices were positively associated with hypothyroid status after FDR correction (q=0.002-0.036). NHHR showed the largest standardized OR point estimate (OR = 1.70, 95% CI: 1.28-2.25). In the common complete-case sample of 404 patients, seven associations remained statistically significant, whereas the association for TG was weaker (q=0.059). The hypothyroid-status group comprised 173 patients with a subclinical hypothyroid pattern and 48 with an overt hypothyroid pattern. All eight measures were associated with the overt pattern, whereas only NHHR remained associated with the subclinical pattern after FDR correction. Six measures were also associated with higher TSH when TSH was analyzed continuously. In exploratory analyses of NHHR, AIP, and TyG, no significant interactions were found by sex, age group, or laboratory-derived diabetes status.
Conclusion: In patients with HT, all eight lipid-related parameters and indices were positively associated with TSH-defined hypothyroid status. The associations were more consistent for the overt hypothyroid pattern; after FDR correction, only NHHR remained associated with the subclinical hypothyroid pattern.
Related
- Autoimmune hepatitis following long-term denosumab therapy in a patient with Hashimoto thyroiditis
- CD10-Positive Extranodal Marginal Zone Lymphoma of the Thyroid Arising in Hashimoto’s Thyroiditis: A Rare Diagnostic Challenge
- Natural Products in Hashimoto’s Thyroiditis: Therapeutic and Thyroid-Disrupting Effects—A Critical Narrative Review
- Hashimoto Thyroiditis Modifies the Association Between Nuclear Atypia and Malignancy in Bethesda III Thyroid Nodules
- Food intolerance/malabsorption in Hashimoto's thyroiditis.
BibTeX
@article{wang2026associations,
title = {{Associations of lipid-related parameters and indices with TSH-defined hypothyroid status in patients with Hashimoto’s thyroiditis: a retrospective cross-sectional study}},
author = {Jie Wang and Hao Wang and Shuo Wang and Zhen Su and Wenjing Yao and Jianfeng Liu and Yanshu Li and Meng Jia},
journal = {Frontiers in Endocrinology},
year = {2026},
month = nov,
doi = {10.3389/fendo.2026.1952851},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1952851/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Associations of lipid-related parameters and indices with TSH-defined hypothyroid status in patients with Hashimoto’s thyroiditis: a retrospective cross-sectional study
AU - Jie Wang
AU - Hao Wang
AU - Shuo Wang
AU - Zhen Su
AU - Wenjing Yao
AU - Jianfeng Liu
AU - Yanshu Li
AU - Meng Jia
PY - 2026
DA - 2026/11/04
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.1952851
UR - https://www.frontiersin.org/articles/10.3389/fendo.2026.1952851/full
AB - Objective: To examine the associations of eight lipid-related parameters and indices with thyroid-stimulating hormone (TSH)-defined hypothyroid status in patients with Hashimoto’s thyroiditis (HT). Methods: This retrospective cross-sectional study included 422 patients with HT. Hypothyroid status was defined as TSH ≥4.5 mIU/L. Associations were estimated using multivariable logistic regression adjusted for age, sex, and laboratory-derived diabetes status. Secondary analyses distinguished non-hypothyroid status, a subclinical hypothyroid pattern, and an overt hypothyroid pattern according to TSH and free thyroxine levels, and analyzed TSH as a continuous outcome. P values were adjusted using the Benjamini-Hochberg false discovery rate procedure. Results: Among the 422 patients, 221 had TSH-defined hypothyroid status and 201 had non-hypothyroid status. All eight parameters and indices were positively associated with hypothyroid status after FDR correction (q=0.002-0.036). NHHR showed the largest standardized OR point estimate (OR = 1.70, 95% CI: 1.28-2.25). In the common complete-case sample of 404 patients, seven associations remained statistically significant, whereas the association for TG was weaker (q=0.059). The hypothyroid-status group comprised 173 patients with a subclinical hypothyroid pattern and 48 with an overt hypothyroid pattern. All eight measures were associated with the overt pattern, whereas only NHHR remained associated with the subclinical pattern after FDR correction. Six measures were also associated with higher TSH when TSH was analyzed continuously. In exploratory analyses of NHHR, AIP, and TyG, no significant interactions were found by sex, age group, or laboratory-derived diabetes status. Conclusion: In patients with HT, all eight lipid-related parameters and indices were positively associated with TSH-defined hypothyroid status. The associations were more consistent for the overt hypothyroid pattern; after FDR correction, only NHHR remained associated with the subclinical hypothyroid pattern.
SN - 1664-2392
ER -