Association of Score for Allergic Rhinitis with Serum Total IgE and Clinical Characteristics in Patients with Allergic Rhinitis
- 1Demonstrator of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University
- 2Assistant Professor of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University
- 3Professor of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University
Abstract
Background: Allergic rhinitis (AR) is a common immunoglobulin E (IgE)-mediated disorder with variable clinical expression. The Score for Allergic Rhinitis (SFAR) is a practical screening and probability tool, while serum total IgE may provide complementary information regarding systemic atopic activity. This study assessed the association between SFAR score, serum total IgE, and selected clinical characteristics in patients with AR. Methods: This case-control study included 33 patients with clinically diagnosed AR and 33 apparently healthy controls . SFAR was recorded for all participants. Patients underwent structured clinical assessment, skin prick testing, measurement of serum total IgE by enzyme-linked immunosorbent assay. Associations of serum total IgE with SFAR score, family history,identifiable allergy triggers were analyzed. Results: Mean SFAR score was significantly higher in patients than controls (9.33±1.38 vs. 2.41±1.05; P<0.001). Among patients, SFAR ranged from 7 to 13, with 66.6% scoring between 8 10. Serum total IgE showed a strong positive correlation with SFAR score (r=0.682, P<0.001). Patients with a positive family history had significantly higher serum total IgE than those without (412.6±128.4 vs. 271.4±94.8 IU/mL; P=0.003). Serum total IgE was also significantly higher in patients with identifiable allergy triggers than in those without recognized triggers (398.8±121.6 vs. 238.5±82.9 IU/mL; P=0.001). Conclusion: SFAR scores were substantially higher among patients with AR than controls were positively correlated with serum total IgE. Higher total IgE was also associated with positive family history identifiable triggers. These findings support interpreting SFAR serum total IgE as complementary clinical information rather than as direct measures of AR severity.
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BibTeX
@article{megahed2026association,
title = {{Association of Score for Allergic Rhinitis with Serum Total IgE and Clinical Characteristics in Patients with Allergic Rhinitis}},
author = {Nada Megahed and Rehab Rabie and Laila Al-kady},
journal = {Zagazig University Medical Journal},
year = {2026},
month = oct,
doi = {10.21608/zumj.2026.529283.4826},
url = {https://doi.org/10.21608/zumj.2026.529283.4826},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Association of Score for Allergic Rhinitis with Serum Total IgE and Clinical Characteristics in Patients with Allergic Rhinitis
AU - Nada Megahed
AU - Rehab Rabie
AU - Laila Al-kady
PY - 2026
DA - 2026/10/25
JO - Zagazig University Medical Journal
DO - 10.21608/zumj.2026.529283.4826
UR - https://doi.org/10.21608/zumj.2026.529283.4826
AB - Background: Allergic rhinitis (AR) is a common immunoglobulin E (IgE)-mediated disorder with variable clinical expression. The Score for Allergic Rhinitis (SFAR) is a practical screening and probability tool, while serum total IgE may provide complementary information regarding systemic atopic activity. This study assessed the association between SFAR score, serum total IgE, and selected clinical characteristics in patients with AR. Methods: This case-control study included 33 patients with clinically diagnosed AR and 33 apparently healthy controls . SFAR was recorded for all participants. Patients underwent structured clinical assessment, skin prick testing, measurement of serum total IgE by enzyme-linked immunosorbent assay. Associations of serum total IgE with SFAR score, family history,identifiable allergy triggers were analyzed. Results: Mean SFAR score was significantly higher in patients than controls (9.33±1.38 vs. 2.41±1.05; P<0.001). Among patients, SFAR ranged from 7 to 13, with 66.6% scoring between 8 10. Serum total IgE showed a strong positive correlation with SFAR score (r=0.682, P<0.001). Patients with a positive family history had significantly higher serum total IgE than those without (412.6±128.4 vs. 271.4±94.8 IU/mL; P=0.003). Serum total IgE was also significantly higher in patients with identifiable allergy triggers than in those without recognized triggers (398.8±121.6 vs. 238.5±82.9 IU/mL; P=0.001). Conclusion: SFAR scores were substantially higher among patients with AR than controls were positively correlated with serum total IgE. Higher total IgE was also associated with positive family history identifiable triggers. These findings support interpreting SFAR serum total IgE as complementary clinical information rather than as direct measures of AR severity.
SN - 2357-0717
SN - 1110-1431
ER -