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Peer-reviewedCC BY 4.0Frontiers in Bioscience-Landmark

The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index

  • Pia Chedid
  • Ali Salami
  • Mariam Ibrahim
  • Sophie Visvikis-Siest
  • Said El Shamieh
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Abstract

Background and objectives: Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in VEGFA and other loci were shown to explain more than 50% of its circulating levels. This study investigated the association of those ten VEGF-related SNPs with serum iron levels in a general Lebanese population free of chronic diseases (N = 460). Result: We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (p = 0.002, and p < 0.001, respectively). When taken together, both variables, rs10738760 and BMI, interacted to reduce iron levels (p < 0.001). According to obesity status, the stratification revealed that the effect of rs10738760 was more pronounced in obese than non-obese individuals (p = 0.025). Conclusion: The intergenic SNP rs10738760 is associated with circulating iron levels, and this association depends on BMI status. Although of interest, these results need replication in larger populations from different ancestries.

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Cite

BibTeXRIS
BibTeX
@article{chedid2026association,
  title = {{The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index}},
  author = {Pia Chedid and Ali Salami and Mariam Ibrahim and Sophie Visvikis-Siest and Said El Shamieh},
  journal = {Frontiers in Bioscience-Landmark},
  year = {2026},
  month = sep,
  doi = {10.31083/j.fbl2701027},
  url = {https://hal.univ-lorraine.fr/hal-03549010v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index
AU  - Pia Chedid
AU  - Ali Salami
AU  - Mariam Ibrahim
AU  - Sophie Visvikis-Siest
AU  - Said El Shamieh
PY  - 2026
DA  - 2026/09/01
JO  - Frontiers in Bioscience-Landmark
DO  - 10.31083/j.fbl2701027
UR  - https://hal.univ-lorraine.fr/hal-03549010v1
AB  - Background and objectives: Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in VEGFA and other loci were shown to explain more than 50% of its circulating levels. This study investigated the association of those ten VEGF-related SNPs with serum iron levels in a general Lebanese population free of chronic diseases (N = 460). Result: We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (p = 0.002, and p < 0.001, respectively). When taken together, both variables, rs10738760 and BMI, interacted to reduce iron levels (p < 0.001). According to obesity status, the stratification revealed that the effect of rs10738760 was more pronounced in obese than non-obese individuals (p = 0.025). Conclusion: The intergenic SNP rs10738760 is associated with circulating iron levels, and this association depends on BMI status. Although of interest, these results need replication in larger populations from different ancestries.
SN  - 2768-6701
SN  - 2768-6698
ER  -