VIP-Mediated Syndromes: Contrasting Presentations and Multidisciplinary Management of Two Rare Neuroendocrine Tumors.
- 1Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL.
- 2Department of Gastroenterology and Hepatology, University of Illinois College of Medicine Peoria, Peoria, IL.
Abstract
Vasoactive intestinal peptide (VIP)-secreting tumors are rare neuroendocrine neoplasms that cause severe secretory diarrhea and electrolyte abnormalities. We describe 2 atypical cases requiring multidisciplinary care. One patient had a VIP-secreting pheochromocytoma with elevated VIP and metanephrine levels; symptoms improved after adrenalectomy. The second had a metastatic small intestinal neuroendocrine tumor with persistent VIP-mediated diarrhea despite debulking and somatostatin analog therapy, complicated by anal fissures, trans-sphincteric perianal fistula, and neuropathic pelvic pain. These cases highlight morbidity and potential complications associated with extrapancreatic VIP hypersecretion and the value of coordinated multidisciplinary management to improve outcomes and quality of life.
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BibTeX
@article{kagzi2026vipmediated,
title = {{VIP-Mediated Syndromes: Contrasting Presentations and Multidisciplinary Management of Two Rare Neuroendocrine Tumors.}},
author = {Yusuf Kagzi and Fatima Ahson and Nikhil Kalva and Imran L Balouch},
journal = {ACG case reports journal},
year = {2026},
month = oct,
doi = {10.14309/crj.0000000000002382},
url = {https://europepmc.org/article/MED/42953880},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - VIP-Mediated Syndromes: Contrasting Presentations and Multidisciplinary Management of Two Rare Neuroendocrine Tumors.
AU - Yusuf Kagzi
AU - Fatima Ahson
AU - Nikhil Kalva
AU - Imran L Balouch
PY - 2026
DA - 2026/10/28
JO - ACG case reports journal
DO - 10.14309/crj.0000000000002382
UR - https://europepmc.org/article/MED/42953880
AB - Vasoactive intestinal peptide (VIP)-secreting tumors are rare neuroendocrine neoplasms that cause severe secretory diarrhea and electrolyte abnormalities. We describe 2 atypical cases requiring multidisciplinary care. One patient had a VIP-secreting pheochromocytoma with elevated VIP and metanephrine levels; symptoms improved after adrenalectomy. The second had a metastatic small intestinal neuroendocrine tumor with persistent VIP-mediated diarrhea despite debulking and somatostatin analog therapy, complicated by anal fissures, trans-sphincteric perianal fistula, and neuropathic pelvic pain. These cases highlight morbidity and potential complications associated with extrapancreatic VIP hypersecretion and the value of coordinated multidisciplinary management to improve outcomes and quality of life.
SN - 2326-3253
ER -