Successful delivery after fertility-sparing management for uterine immature teratoma : a case report and literature review
- 1Senior Department of Obstetrics & Gynecology, the Seventh Medical Center of PLA General Hospital, Beijing, China
Abstract
Background: Uterine immature teratoma is an extremely rare neoplasm. No cases of successful pregnancy and delivery following fertility-sparing management have been reported in the literature.
Case presentation: From September 2020 to January 2026, we identified a 36-year-old nulliparous woman diagnosed with uterine immature teratoma, who achieved successful pregnancy and delivery following standardized fertility-sparing management. The patient presented with a four‑month history of abnormal vaginal bleeding. Pelvic contrast‑enhanced magnetic resonance imaging (MRI) revealed a 9.5 cm × 8.5 cm × 7.5 cm mixed cystic‑solid mass in the lower middle uterine cavity. Tumor marker levels were all within normal limits. The patient underwent two surgical procedures. The first was an incomplete tumor resection; histopathological examination confirmed a grade 2 uterine immature teratoma. The second procedure achieved complete tumor resection, and pathological examination of the resected specimen showed a mature teratoma. Postoperatively, the patient received four cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy. One and a half years later, she delivered successfully and has remained recurrence‑free during five years of follow‑up.
Conclusions: This case highlights the diagnostic and therapeutic challenges of uterine immature teratoma. For patients desiring fertility preservation, a fertility-sparing approach may be considered when the disease is confined to the endometrium, in the absence of other malignant components, with grade 1–2 histology, and provided that there is a favorable response to chemotherapy.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12884-026-09727-5.
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BibTeX
@article{zhang2026successful,
title = {{Successful delivery after fertility-sparing management for uterine immature teratoma : a case report and literature review}},
author = {Xiaolan Zhang and Yongxian Lu and Ying Zhao and Ke Niu and Wenying Wang and Hua Yang and Wenjie Shen},
journal = {BMC Pregnancy and Childbirth},
year = {2026},
month = jul,
doi = {10.1186/s12884-026-09727-5},
url = {https://doi.org/10.1186/s12884-026-09727-5},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Successful delivery after fertility-sparing management for uterine immature teratoma : a case report and literature review
AU - Xiaolan Zhang
AU - Yongxian Lu
AU - Ying Zhao
AU - Ke Niu
AU - Wenying Wang
AU - Hua Yang
AU - Wenjie Shen
PY - 2026
DA - 2026/07/30
JO - BMC Pregnancy and Childbirth
DO - 10.1186/s12884-026-09727-5
UR - https://doi.org/10.1186/s12884-026-09727-5
AB - Background: Uterine immature teratoma is an extremely rare neoplasm. No cases of successful pregnancy and delivery following fertility-sparing management have been reported in the literature. Case presentation: From September 2020 to January 2026, we identified a 36-year-old nulliparous woman diagnosed with uterine immature teratoma, who achieved successful pregnancy and delivery following standardized fertility-sparing management. The patient presented with a four‑month history of abnormal vaginal bleeding. Pelvic contrast‑enhanced magnetic resonance imaging (MRI) revealed a 9.5 cm × 8.5 cm × 7.5 cm mixed cystic‑solid mass in the lower middle uterine cavity. Tumor marker levels were all within normal limits. The patient underwent two surgical procedures. The first was an incomplete tumor resection; histopathological examination confirmed a grade 2 uterine immature teratoma. The second procedure achieved complete tumor resection, and pathological examination of the resected specimen showed a mature teratoma. Postoperatively, the patient received four cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy. One and a half years later, she delivered successfully and has remained recurrence‑free during five years of follow‑up. Conclusions: This case highlights the diagnostic and therapeutic challenges of uterine immature teratoma. For patients desiring fertility preservation, a fertility-sparing approach may be considered when the disease is confined to the endometrium, in the absence of other malignant components, with grade 1–2 histology, and provided that there is a favorable response to chemotherapy. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12884-026-09727-5.
SN - 1471-2393
ER -