Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control.
- 1School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
- 2State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
- 3Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting the global swine industry. This review summarizes current knowledge of PRRSV-induced suppression of adaptive immune responses, with particular emphasis on impaired T cell activity, dysregulated B cell responses, delayed and insufficient neutralizing antibody production, and viral strategies that limit effective immune clearance. In addition, recent advances and limitations in vaccine development and antiviral strategies are presented. By integrating insights from viral pathogenesis and host immune responses, this review provides a comprehensive perspective on current challenges and emerging strategies for effective PRRSV control.
Related
- Porcine reproductive and respiratory syndrome virus hijacks the non-canonical enzymatic function of PHGDH to arrest autophagic flux for viral replication
- Evaluation of the efficacy of a live attenuated vaccine (porcimune PRRS MLV) against porcine reproductive and respiratory syndrome virus in landrace piglets.
- Defective viral genomes of porcine reproductive and respiratory syndrome virus type 2: Generation, characterization and interference effects on viral replication
- 112 LightningSeq: a long-read HLA/TCR sequencing platform for scalable profiling of adaptive cellular immunity
- Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability
BibTeX
@article{zhu2026porcine,
title = {{Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control.}},
author = {Ning Zhu and Jincheng Zhong and Zengjun Lu and Jing Zhang},
journal = {Viruses},
year = {2026},
month = sep,
doi = {10.3390/v18101077},
url = {https://europepmc.org/article/MED/42943997},
note = {CC BY},
}
RIS
TY - JOUR
TI - Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control.
AU - Ning Zhu
AU - Jincheng Zhong
AU - Zengjun Lu
AU - Jing Zhang
PY - 2026
DA - 2026/09/01
JO - Viruses
DO - 10.3390/v18101077
UR - https://europepmc.org/article/MED/42943997
AB - Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting the global swine industry. This review summarizes current knowledge of PRRSV-induced suppression of adaptive immune responses, with particular emphasis on impaired T cell activity, dysregulated B cell responses, delayed and insufficient neutralizing antibody production, and viral strategies that limit effective immune clearance. In addition, recent advances and limitations in vaccine development and antiviral strategies are presented. By integrating insights from viral pathogenesis and host immune responses, this review provides a comprehensive perspective on current challenges and emerging strategies for effective PRRSV control.
SN - 1999-4915
ER -