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Peer-reviewedCC BY-NC 4.0Nucleic Acids Research

ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes

  • Iro N Chasapi1,2
  • Eleni Aplakidou1,3
  • Maria N Chasapi1,3
  • Efthimia Lamari1,3,4
  • Alexandros Galaras1
  • Sophia Diplari1,4
  • Ioannis Iliopoulos3
  • Ioannis Z Emiris2,5
  • Ilias Georgakopoulos-Soares6
  • Solenn Patalano1,7
  • Dimitrios J Stravopodis8
  • Evangelos Karatzas9
3 more authors
  • Fotis A Baltoumas1
  • Nikos C Kyrpides10
  • Georgios A Pavlopoulos1,11
11 affiliations
  1. 1Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari 16672 ,
  2. 2Department of Informatics and Telecommunications, National and Kapodistrian University of Athens , Athens 16122 ,
  3. 3Division of Basic Sciences, University of Crete Medical School , 71110 Heraklion ,
  4. 4Medical School of Athens, National and Kapodistrian University of Athens , Goudi 11527 ,
  5. 5Athena Research Center , Marousi 15125 ,
  6. 6Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute , 1400 Barbara Jordan Blvd., Austin, TX 78723 ,
  7. 7Observatory of biodiversity dynamics, QUYFIN , Athens 17562 ,
  8. 8Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA) , Athens 15701 ,
  9. 9European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridge CB10 1SD ,
  10. 10DOE Joint Genome Institute, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley, CA 94720 ,
  11. 11Division of Biological and Life Sciences, Mohamed bin Zayed University of Artificial Intelligence (MBZUAI) , Building 1B, Masdar City, Abu Dhabi SE45 05 ,
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Abstract

Metagenomic studies of arthropod-associated microbiomes have generated vast amounts of sequence data, yet the functional and structural organization of these proteins remains largely unexplored. Here, we present ArthroVerse, the first comprehensive database of protein families derived from arthropod-associated metagenomes. Non-redundant protein families were generated after rigorous filtering, deduplication, and clustering. The protein families were further annotated with microbial taxonomy, host associations, protein structural information, and carbohydrate-active enzymes predictions. The resulting dataset integrates both metagenomic and reference genome-derived proteins, enabling systematic exploration of functional diversity, evolutionary relationships, and host-microbe interactions in insect microbiomes. ArthroVerse provides a valuable resource for the study of microbial ecology and arthropod physiology, offering unprecedented insight into the protein landscape of insect-associated microbial communities. ArthroVerse is publicly accessible at https://envofams.org/arthroverse/.

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Cite

BibTeXRIS
BibTeX
@article{chasapi2026arthroverse,
  title = {{ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes}},
  author = {Iro N Chasapi and Eleni Aplakidou and Maria N Chasapi and Efthimia Lamari and Alexandros Galaras and Sophia Diplari and Ioannis Iliopoulos and Ioannis Z Emiris and Ilias Georgakopoulos-Soares and Solenn Patalano and Dimitrios J Stravopodis and Evangelos Karatzas and Fotis A Baltoumas and Nikos C Kyrpides and Georgios A Pavlopoulos},
  journal = {Nucleic Acids Research},
  year = {2026},
  month = oct,
  doi = {10.1093/nar/gkag1067},
  url = {https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1067/9002503},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes
AU  - Iro N Chasapi
AU  - Eleni Aplakidou
AU  - Maria N Chasapi
AU  - Efthimia Lamari
AU  - Alexandros Galaras
AU  - Sophia Diplari
AU  - Ioannis Iliopoulos
AU  - Ioannis Z Emiris
AU  - Ilias Georgakopoulos-Soares
AU  - Solenn Patalano
AU  - Dimitrios J Stravopodis
AU  - Evangelos Karatzas
AU  - Fotis A Baltoumas
AU  - Nikos C Kyrpides
AU  - Georgios A Pavlopoulos
PY  - 2026
DA  - 2026/10/27
JO  - Nucleic Acids Research
DO  - 10.1093/nar/gkag1067
UR  - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1067/9002503
AB  - Metagenomic studies of arthropod-associated microbiomes have generated vast amounts of sequence data, yet the functional and structural organization of these proteins remains largely unexplored. Here, we present ArthroVerse, the first comprehensive database of protein families derived from arthropod-associated metagenomes. Non-redundant protein families were generated after rigorous filtering, deduplication, and clustering. The protein families were further annotated with microbial taxonomy, host associations, protein structural information, and carbohydrate-active enzymes predictions. The resulting dataset integrates both metagenomic and reference genome-derived proteins, enabling systematic exploration of functional diversity, evolutionary relationships, and host-microbe interactions in insect microbiomes. ArthroVerse provides a valuable resource for the study of microbial ecology and arthropod physiology, offering unprecedented insight into the protein landscape of insect-associated microbial communities. ArthroVerse is publicly accessible at https://envofams.org/arthroverse/.
SN  - 0305-1048
SN  - 1362-4962
ER  -