Stress-induced Metabolic Remodeling of Adipose and Brain Tissue revealed by Positron Emission Tomography

Abstract

Stress impacts our health and triggers physiological adaptations, yet the metabolic programs engaged during stress remain incompletely understood. To fill this knowledge gap, we utilized total-body positron emission tomography (PET), multi-OMICS, and endocrine profiling to assess how various murine stress models affect systemic metabolic remodeling. We found that acute immobilization and surgery activate brown adipose tissue as part of the stress response, independently of hypothermia, thereby acting as a highly stress-sensitive metabolic hub. Additionally, we identified stress-specific hypo- and hypermetabolic signatures in different brain regions, and distinguished networks between brain and adipose tissue depots across the different stress groups. Our work presents a novel perspective on stress and its mobilization of metabolic resources and identifies PET imaging of brain and adipose tissue as a valuable, minimally invasive technique for tracking metabolic stress responses in mice, with relevance for animal welfare and disease models, and translational impact for mental health studies and preventive medicine.

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BibTeX RIS

BibTeX

@misc{krisch2026stressinduced,
  title = {{Stress-induced Metabolic Remodeling of Adipose and Brain Tissue revealed by Positron Emission Tomography}},
  author = {M. Krisch and O. Özer and J. L. Wilson and S. Macho-Maschler and P. Ettel and H. Vrban and A. Grentner and B. K. Geist and C. T. S. Mertel and U. Ustsinau and O. Kulterer and J. Friske and T. Wanek and C. Kuntner and T. Helbich and S. Grünert and R. Palme and F. W. Kiefer and T. Weichhart and C. Philippe and M. Hacker and C. Vraka},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.09.749803},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.09.749803v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - Stress-induced Metabolic Remodeling of Adipose and Brain Tissue revealed by Positron Emission Tomography
AU  - M. Krisch
AU  - O. Özer
AU  - J. L. Wilson
AU  - S. Macho-Maschler
AU  - P. Ettel
AU  - H. Vrban
AU  - A. Grentner
AU  - B. K. Geist
AU  - C. T. S. Mertel
AU  - U. Ustsinau
AU  - O. Kulterer
AU  - J. Friske
AU  - T. Wanek
AU  - C. Kuntner
AU  - T. Helbich
AU  - S. Grünert
AU  - R. Palme
AU  - F. W. Kiefer
AU  - T. Weichhart
AU  - C. Philippe
AU  - M. Hacker
AU  - C. Vraka
PY  - 2026
DA  - 2026/09/09
PB  - bioRxiv
DO  - 10.64898/2026.09.09.749803
UR  - https://www.biorxiv.org/content/10.64898/2026.09.09.749803v1
AB  - Stress impacts our health and triggers physiological adaptations, yet the metabolic programs engaged during stress remain incompletely understood. To fill this knowledge gap, we utilized total-body positron emission tomography (PET), multi-OMICS, and endocrine profiling to assess how various murine stress models affect systemic metabolic remodeling. We found that acute immobilization and surgery activate brown adipose tissue as part of the stress response, independently of hypothermia, thereby acting as a highly stress-sensitive metabolic hub. Additionally, we identified stress-specific hypo- and hypermetabolic signatures in different brain regions, and distinguished networks between brain and adipose tissue depots across the different stress groups. Our work presents a novel perspective on stress and its mobilization of metabolic resources and identifies PET imaging of brain and adipose tissue as a valuable, minimally invasive technique for tracking metabolic stress responses in mice, with relevance for animal welfare and disease models, and translational impact for mental health studies and preventive medicine.
ER  -

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