Peer-reviewedCC BY-NC-NDCirculation Journal
Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease
Abstract
BACKGROUND: Visceral fat (VF), particularly epicardial adipose tissue (EAT), plays a crucial role in the development of coronary artery disease (CAD). Cathelicidin (LL37) is an antimicrobial peptide involved in innate immunity and has been implicated in inflammatory processes. However, the relationship between VF accumulation, cathelicidin, and atherosclerosis remains unclear. METHODS AND RESULTS: mice without affecting blood pressure or lipid profiles. CONCLUSIONS: LL37 is associated with VF accumulation and CAD. However, these findings are exploratory and warrant prospective validation to determine its potential utility as a biomarker.
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BibTeX
@article{taniguchi2026cathelicidin,
title = {{Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease}},
author = {Motoki Taniguchi and Akira Taruya and Chie Kitahara and Shingo Ota and Takashi Kato and Yuki Desaki and Izumi Sasaki and Yosuke Katayama and Teruaki Wada and Masahiro Takahata and Keisuke Satogami and Yuichi Ozaki and Manabu Kashiwagi and Yasutsugu Shiono and Kentaro Honda and Takashi Yamano and Kazushi Takemoto and Akio Kuroi and Hironori Kitabata and Hiroaki Hemmi and Takaaki Matsuoka and Yoshiharu Nishimura and Atsushi Tanaka},
journal = {Circulation Journal},
year = {2026},
month = jul,
doi = {10.1253/circj.cj-25-0829},
url = {https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0829/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease
AU - Motoki Taniguchi
AU - Akira Taruya
AU - Chie Kitahara
AU - Shingo Ota
AU - Takashi Kato
AU - Yuki Desaki
AU - Izumi Sasaki
AU - Yosuke Katayama
AU - Teruaki Wada
AU - Masahiro Takahata
AU - Keisuke Satogami
AU - Yuichi Ozaki
AU - Manabu Kashiwagi
AU - Yasutsugu Shiono
AU - Kentaro Honda
AU - Takashi Yamano
AU - Kazushi Takemoto
AU - Akio Kuroi
AU - Hironori Kitabata
AU - Hiroaki Hemmi
AU - Takaaki Matsuoka
AU - Yoshiharu Nishimura
AU - Atsushi Tanaka
PY - 2026
DA - 2026/07/24
JO - Circulation Journal
DO - 10.1253/circj.cj-25-0829
UR - https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0829/_article
AB - BACKGROUND: Visceral fat (VF), particularly epicardial adipose tissue (EAT), plays a crucial role in the development of coronary artery disease (CAD). Cathelicidin (LL37) is an antimicrobial peptide involved in innate immunity and has been implicated in inflammatory processes. However, the relationship between VF accumulation, cathelicidin, and atherosclerosis remains unclear. METHODS AND RESULTS: mice without affecting blood pressure or lipid profiles. CONCLUSIONS: LL37 is associated with VF accumulation and CAD. However, these findings are exploratory and warrant prospective validation to determine its potential utility as a biomarker.
SN - 1347-4820
SN - 1346-9843
ER -