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PreprintCC BYChemRxiv

The Design and Application of Diureido Functionalized Spiroligomers as Diphosphate Receptors

  • Yanfeng Fan
  • Kyle Brunner
  • Chongsong Xu
  • Owen O’Sullivan
  • Melody Pham
  • Michael J. Zdilla
  • Christian E. Schafmeister
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Abstract

Spiroligomers are rigid, stereochemically defined scaffolds that can be programmed to display functional groups in precise three-dimensional constellations. We utilize this scaffold to position two urea groups in a preorganized geometry for anion binding. Among the receptors synthesized, the spiroligomer with RRRR-configuration displayed the strongest affinity for hydrogen pyrophosphate H2PPi (H2P2O7

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Cite

BibTeXRIS
BibTeX
@misc{fan2026design,
  title = {{The Design and Application of Diureido Functionalized Spiroligomers as Diphosphate Receptors}},
  author = {Yanfeng Fan and Kyle Brunner and Chongsong Xu and Owen O’Sullivan and Melody Pham and Michael J. Zdilla and Christian E. Schafmeister},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15007885/v2},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007885/v2},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - The Design and Application of Diureido Functionalized Spiroligomers as Diphosphate Receptors
AU  - Yanfeng Fan
AU  - Kyle Brunner
AU  - Chongsong Xu
AU  - Owen O’Sullivan
AU  - Melody Pham
AU  - Michael J. Zdilla
AU  - Christian E. Schafmeister
PY  - 2026
DA  - 2026/09/14
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15007885/v2
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007885/v2
AB  - Spiroligomers are rigid, stereochemically defined scaffolds that can be programmed to display functional groups in precise three-dimensional constellations. We utilize this scaffold to position two urea groups in a preorganized geometry for anion binding. Among the receptors synthesized, the spiroligomer with RRRR-configuration displayed the strongest affinity for hydrogen pyrophosphate H2PPi (H2P2O7
ER  -