Quantitative Ultrasound Characterizes Perfusion Trajectories in Healthy and Inflamed Gingival Wound Healing
Abstract
Rationale and Objectives: Visual examination of extraction-site healing provides limited insight into underlying vascular recovery. We developed a quantitative ultrasound framework to assess gingival perfusion and persistent inflammation. Materials and Methods: Patients (n = 51) undergoing extraction and socket preservation were imaged longitudinally using color-flow ultrasound and laser speckle contrast analysis (LASCA) from 2 weeks to 3 months after extraction. Pre-scan-converted Total Recall Imaging (TRI) data with phase information were processed using scan conversion, bilateral filtering, and power estimation to derive velocity-weighted color pixel density (CPDvel). Gingival regions of interest were automatically segmented using deep learning and assessed with Dice and Bland-Altman analyses. CPDvel was compared between healthy and inflamed visits in early (<35 days) and recovery (>35 days) periods and with LASCA. Results: Segmentation achieved a mean Dice score of 0.98 and median of 0.99 (IQR, 0.98-0.99), with minimal area bias (-0.005%; 95% limits of agreement, -1.68% to 1.67%). Median CPDvel decreased by 81% between early and recovery periods in healthy visits (p = 0.01), compared with a nonsignificant 26% reduction in inflamed visits (p = 0.31). During recovery, CPDvel was higher in inflamed than healthy visits (0.12 vs 0.03 cm/s; p = 0.04). LASCA showed smaller reductions (13% and 9%, respectively). CPDvel was positively correlated with LASCA in healthy (one-sided p = 0.03) and inflamed visits (one-sided p = 0.13). Conclusions: TRI-based quantitative ultrasound enabled automated perfusion assessment with reduced dependence on scanner display settings. Distinct perfusion patterns and more pronounced temporal changes than LASCA support its potential for noninvasive monitoring of oral wound healing and persistent inflammation.
Related
- Quantitative Ultrasound Perfusion Biomarker: Cross-Modality Validation with Laser Speckle Imaging
- A Blood–Brain Barrier-on-Chip Approaching In Vivo Tightness for Quantitative Ultrasound-Mediated Opening
- Buccal-Lingual Analysis and Inflammation Tracking in Oral Soft Tissues Using Quantitative Ultrasound: A Preclinical Study
- Information Causality Characterizes the Set of Quantum Correlations in the Simplest Bell Scenario
- Ventilation Perfusion Functional Difference Images in Lung SPECT: a linear and symmetrical scale as an alternative to the Ventilation Perfusion Ratio
BibTeX
@misc{tai2026quantitative,
title = {{Quantitative Ultrasound Characterizes Perfusion Trajectories in Healthy and Inflamed Gingival Wound Healing}},
author = {Haowei Tai and Oscar Duran-Garnica and Karen Villarreal and Hsun-Liang Chan and Oliver D. Kripfgans},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2610.41897},
eprint = {2610.41897},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2610.41897},
}
RIS
TY - UNPB
TI - Quantitative Ultrasound Characterizes Perfusion Trajectories in Healthy and Inflamed Gingival Wound Healing
AU - Haowei Tai
AU - Oscar Duran-Garnica
AU - Karen Villarreal
AU - Hsun-Liang Chan
AU - Oliver D. Kripfgans
PY - 2026
DA - 2026/10/30
PB - arXiv
DO - 10.48550/arxiv.2610.41897
UR - https://arxiv.org/abs/2610.41897
AB - Rationale and Objectives: Visual examination of extraction-site healing provides limited insight into underlying vascular recovery. We developed a quantitative ultrasound framework to assess gingival perfusion and persistent inflammation. Materials and Methods: Patients (n = 51) undergoing extraction and socket preservation were imaged longitudinally using color-flow ultrasound and laser speckle contrast analysis (LASCA) from 2 weeks to 3 months after extraction. Pre-scan-converted Total Recall Imaging (TRI) data with phase information were processed using scan conversion, bilateral filtering, and power estimation to derive velocity-weighted color pixel density (CPDvel). Gingival regions of interest were automatically segmented using deep learning and assessed with Dice and Bland-Altman analyses. CPDvel was compared between healthy and inflamed visits in early (<35 days) and recovery (>35 days) periods and with LASCA. Results: Segmentation achieved a mean Dice score of 0.98 and median of 0.99 (IQR, 0.98-0.99), with minimal area bias (-0.005%; 95% limits of agreement, -1.68% to 1.67%). Median CPDvel decreased by 81% between early and recovery periods in healthy visits (p = 0.01), compared with a nonsignificant 26% reduction in inflamed visits (p = 0.31). During recovery, CPDvel was higher in inflamed than healthy visits (0.12 vs 0.03 cm/s; p = 0.04). LASCA showed smaller reductions (13% and 9%, respectively). CPDvel was positively correlated with LASCA in healthy (one-sided p = 0.03) and inflamed visits (one-sided p = 0.13). Conclusions: TRI-based quantitative ultrasound enabled automated perfusion assessment with reduced dependence on scanner display settings. Distinct perfusion patterns and more pronounced temporal changes than LASCA support its potential for noninvasive monitoring of oral wound healing and persistent inflammation.
ER -