Water, lithium and sodium: watch out for dangerous injuries
Abstract
Nephrogenic diabetes insipidus due to the inability of the kidneys to concentrate urine is frequently observed during lithium therapy. Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water. This disease is characterized by polyuria - polydipsia leading to intracellular dehydration and hypernatremia. Water deprivation test is performed to confirm insipidus diabetes. The desmopressin permits to distinguish nephrogenic from cranial insipidus diabetes. We report the case of a 64 years old women who presented with global dehydration and severe hypernatremia. Four years ago, she was hospitalized for nephrogenic diabetes insipidus related to a self-induced lithium intoxication. Persistent nephrogenic insipidus diabetes after cessation of lithium therapy are described in literature, and this hypothesis may be consistent with this case report.
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BibTeX
@article{fayolle2026water,
title = {{Water, lithium and sodium: watch out for dangerous injuries}},
author = {Martin Fayolle and Jean-Sébastien Souweine and Olivier Mathieu and Anne-Sophie Bargnoux and Jean-Paul Cristol and Stéphanie Badiou},
journal = {Annales de Biologie Clinique},
year = {2026},
month = oct,
doi = {10.1684/abc.2020.1570},
url = {https://hal.science/hal-05785812v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Water, lithium and sodium: watch out for dangerous injuries
AU - Martin Fayolle
AU - Jean-Sébastien Souweine
AU - Olivier Mathieu
AU - Anne-Sophie Bargnoux
AU - Jean-Paul Cristol
AU - Stéphanie Badiou
PY - 2026
DA - 2026/10/08
JO - Annales de Biologie Clinique
DO - 10.1684/abc.2020.1570
UR - https://hal.science/hal-05785812v1
AB - Nephrogenic diabetes insipidus due to the inability of the kidneys to concentrate urine is frequently observed during lithium therapy. Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water. This disease is characterized by polyuria - polydipsia leading to intracellular dehydration and hypernatremia. Water deprivation test is performed to confirm insipidus diabetes. The desmopressin permits to distinguish nephrogenic from cranial insipidus diabetes. We report the case of a 64 years old women who presented with global dehydration and severe hypernatremia. Four years ago, she was hospitalized for nephrogenic diabetes insipidus related to a self-induced lithium intoxication. Persistent nephrogenic insipidus diabetes after cessation of lithium therapy are described in literature, and this hypothesis may be consistent with this case report.
SN - 0003-3898
ER -