Skip to content
DraconiticResearch
Search Sources API
178,970 studies31 sourcesUpdated 42 min ago
Peer-reviewedCC BYCureus

Prenatal Diagnosis of Alobar Holoprosencephaly With Cyclopia and Proboscis: A Case Report.

  • Manisha Mahajan1
  • Varun Mahajan2
  • Chandla Nikita Kishor Singh3
  1. 1Department of Radiology, Government Medical College, Udhampur, IND.
  2. 2Department of General Surgery, Government Medical College, Jammu, IND.
  3. 3Department of Anesthesia and Critical Care, Government Medical College, Jammu, IND.
Read full textPDFDOICite

Abstract

Alobar holoprosencephaly (HPE) is a severe developmental abnormality of the fetal brain. It can also be associated with major facial abnormalities. We report a case diagnosed during a routine ultrasound scan at 22 weeks of pregnancy in a 26-year-old G2P1L1 woman. Ultrasound showed a single ventricular cavity, an absent interhemispheric fissure and falx cerebri, and fused thalami. Facial examination showed a single median orbit and a midline proboscis, consistent with cyclopia. No other structural abnormalities were seen. After counseling about the severe nature and poor prognosis of the condition, the pregnancy was terminated at 23 weeks. This case highlights the importance of examining the fetal face when alobar HPE is suspected on ultrasound.

Related

  1. Prenatal ultrasound diagnosis and follow-up tracking of a case of congenital coronary artery fistula.
    Haoliang Huang, Yuxia Liang, Yuhua Yu +2
    BMC cardiovascular disordersPeer-reviewedCC BY-NC-NDFull textCardiovascular medicineEurope PMCDOAJ
  2. Prenatal Diagnosis and Perinatal Management of Acrania Progressing to Anencephaly
    Cesar Alas-Pineda, Oswaldo Montes Bardales, Anahi Pacheco +3
    CureusPeer-reviewedCC BYFull textObstetrics, gynaecology & paediatricsEurope PMCPMC
  3. Prenatal diagnosis of Lowe syndrome in a male fetus with isolated bilateral cataract
    Flavien Rouxel, Julien Fauré, Jean-Michel Faure +7
    HeliyonPeer-reviewedCC BY-NC-ND4 citedObstetrics, gynaecology & paediatricsHAL
  4. Case Report: Prenatal diagnosis of congenital knee dislocation caused by BICD2 gene variant.
    Xiaohua Ge, Wencong Li, Hong Wei +1
    Frontiers in geneticsPeer-reviewedCC BYFull textObstetrics, gynaecology & paediatricsEurope PMCPMC
  5. Prenatal Diagnosis of Recurrent Fetal Intracranial Hemorrhage and a Maternally Inherited COL4A1 Variant of Uncertain Significance: A Case Report With Maternal Reverse Phenotyping
    Wei Shi, Hongjing Xu, Caihong Pu +7
    Clinical Case ReportsPeer-reviewedCC BYFull textObstetrics, gynaecology & paediatricsDOAJEurope PMC

Cite

BibTeXRIS
BibTeX
@article{mahajan2026prenatal,
  title = {{Prenatal Diagnosis of Alobar Holoprosencephaly With Cyclopia and Proboscis: A Case Report.}},
  author = {Manisha Mahajan and Varun Mahajan and Chandla Nikita Kishor Singh},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116592},
  url = {https://europepmc.org/article/MED/42904174},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Prenatal Diagnosis of Alobar Holoprosencephaly With Cyclopia and Proboscis: A Case Report.
AU  - Manisha Mahajan
AU  - Varun Mahajan
AU  - Chandla Nikita Kishor Singh
PY  - 2026
DA  - 2026/09/20
JO  - Cureus
DO  - 10.7759/cureus.116592
UR  - https://europepmc.org/article/MED/42904174
AB  - Alobar holoprosencephaly (HPE) is a severe developmental abnormality of the fetal brain. It can also be associated with major facial abnormalities. We report a case diagnosed during a routine ultrasound scan at 22 weeks of pregnancy in a 26-year-old G2P1L1 woman. Ultrasound showed a single ventricular cavity, an absent interhemispheric fissure and falx cerebri, and fused thalami. Facial examination showed a single median orbit and a midline proboscis, consistent with cyclopia. No other structural abnormalities were seen. After counseling about the severe nature and poor prognosis of the condition, the pregnancy was terminated at 23 weeks. This case highlights the importance of examining the fetal face when alobar HPE is suspected on ultrasound.
SN  - 2168-8184
ER  -