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Peer-reviewedCC BY-NCBMJ open respiratory research

Mortality and Risk Factors Associated with Death in Patients with Obesity Hypoventilation Syndrome and of Predominantly Afro-Caribbean Origin in Martinique

  • M. Agossou
  • A. Monfort-Brafine
  • C. Fagour
  • B. Awanou
  • S. Metanmo
  • M.-E. Jean-Charles-Catan
  • O. l'Heveder
  • J. Inamo
  • M. Duféal
  • M. Provost
  • N. Ahouansou
  • M. Andreu
3 more authors
  • J.-M. Arnal
  • C. Raherison-Semjen
  • M. Dramé
Open at sourcePDFDOICite

Abstract

BACKGROUND: Obesity hypoventilation syndrome (OHS) is a respiratory complication of obesity. Mortality from OHS is non-negligible. Risk factors for OHS-related mortality are not well established and vary in the literature. This study aimed to assess mortality from OHS in patients in Martinique and to identify risk factors for death. METHODS: We performed a single-centre, observational study from 1 January 2019 to 31 December 2024, including patients with OHS. RESULTS: Among 167 included patients, 44 (26.4%) died as of 31 December 2024. 5-year mortality was 12.6%.In multivariable Cox regression, independent predictors of mortality were: OHS diagnosed during acute respiratory failure (HR 6.60, 95% CI 1.50 to 29.10), irregular follow-up (HR 5, 95% CI 1.82 to 14.29), left heart disease (HR 3.63, 95% CI 1.51 to 8.70), lower haematocrit (HR 1.12 per percentage point, 95% CI 1.03 to 1.22) and older age at diagnosis (HR 1.04 per year, 95% CI 1.01 to 1.08). CONCLUSION: Mortality among patients with OHS in Martinique remains high. Strategies to improve early diagnosis, cardiovascular risk management and long-term follow-up are essential to improving outcomes in this high-risk population.

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Cite

BibTeXRIS
BibTeX
@article{agossou2026mortality,
  title = {{Mortality and Risk Factors Associated with Death in Patients with Obesity Hypoventilation Syndrome and of Predominantly Afro-Caribbean Origin in Martinique}},
  author = {M. Agossou and A. Monfort-Brafine and C. Fagour and B. Awanou and S. Metanmo and M.-E. Jean-Charles-Catan and O. l'Heveder and J. Inamo and M. Duféal and M. Provost and N. Ahouansou and M. Andreu and J.-M. Arnal and C. Raherison-Semjen and M. Dramé},
  journal = {BMJ open respiratory research},
  year = {2026},
  month = nov,
  doi = {10.1136/bmjresp-2025-003819},
  url = {https://hal.science/hal-05858036v1},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Mortality and Risk Factors Associated with Death in Patients with Obesity Hypoventilation Syndrome and of Predominantly Afro-Caribbean Origin in Martinique
AU  - M. Agossou
AU  - A. Monfort-Brafine
AU  - C. Fagour
AU  - B. Awanou
AU  - S. Metanmo
AU  - M.-E. Jean-Charles-Catan
AU  - O. l'Heveder
AU  - J. Inamo
AU  - M. Duféal
AU  - M. Provost
AU  - N. Ahouansou
AU  - M. Andreu
AU  - J.-M. Arnal
AU  - C. Raherison-Semjen
AU  - M. Dramé
PY  - 2026
DA  - 2026/11/09
JO  - BMJ open respiratory research
DO  - 10.1136/bmjresp-2025-003819
UR  - https://hal.science/hal-05858036v1
AB  - BACKGROUND: Obesity hypoventilation syndrome (OHS) is a respiratory complication of obesity. Mortality from OHS is non-negligible. Risk factors for OHS-related mortality are not well established and vary in the literature. This study aimed to assess mortality from OHS in patients in Martinique and to identify risk factors for death. METHODS: We performed a single-centre, observational study from 1 January 2019 to 31 December 2024, including patients with OHS. RESULTS: Among 167 included patients, 44 (26.4%) died as of 31 December 2024. 5-year mortality was 12.6%.In multivariable Cox regression, independent predictors of mortality were: OHS diagnosed during acute respiratory failure (HR 6.60, 95% CI 1.50 to 29.10), irregular follow-up (HR 5, 95% CI 1.82 to 14.29), left heart disease (HR 3.63, 95% CI 1.51 to 8.70), lower haematocrit (HR 1.12 per percentage point, 95% CI 1.03 to 1.22) and older age at diagnosis (HR 1.04 per year, 95% CI 1.01 to 1.08). CONCLUSION: Mortality among patients with OHS in Martinique remains high. Strategies to improve early diagnosis, cardiovascular risk management and long-term follow-up are essential to improving outcomes in this high-risk population.
SN  - 2052-4439
ER  -